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Cells
Volume 10
Issue 12
10.3390/cells10123537
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Review
Peer-Review Record

Ion Channels and Pumps in Autophagy: A Reciprocal Relationship

Cells 2021, 10(12), 3537; https://doi.org/10.3390/cells10123537
by Hussein Abuammar 1,2,†, Arindam Bhattacharjee 1,†, Zsófia Simon-Vecsei 3,†, András Blastyák 1,†, Gábor Csordás 1,†, Tibor Páli 4 and Gábor Juhász 1,3,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cells 2021, 10(12), 3537; https://doi.org/10.3390/cells10123537
Submission received: 15 November 2021 / Revised: 7 December 2021 / Accepted: 8 December 2021 / Published: 14 December 2021
(This article belongs to the Special Issue 10th Anniversary of Cells—Advances in Autophagy)

Round 1

Reviewer 1 Report

This Review is looking very interesting and modern. Very nice two Figures (illustration). The topic of this Review is closely related to regulation of lysosomes function in physiology and pathology (neurodegenerative diseases).

 

Author Response

Response to Reviewer 1

 

This Review is looking very interesting and modern. Very nice two Figures (illustration). The topic of this Review is closely related to regulation of lysosomes function in physiology and pathology (neurodegenerative diseases).

 

RESPONSE.

We thank the reviewer for the positive remarks.

 

Reviewer 2 Report

The review by Abuammar et al. is timely given the several recent papers highlighting the important roles of ion channels and pumps in autophagy and lysosomes. Although their roles are very complicated, this review nicely summarized them and is fairly comprehensive. The figures are also very valuable for researchers in this field.

Minor comment:

In Fig1, mTOR is inhibited by TRPML1-derived calcium. Is this OK? The Ref(66) paper may reveal the positive regulation of mTORC1 by lysosomal calcium and calmodulin (PMID: 27787197).

Author Response

Response to Reviewer 2

The review by Abuammar et al. is timely given the several recent papers highlighting the important roles of ion channels and pumps in autophagy and lysosomes. Although their roles are very complicated, this review nicely summarized them and is fairly comprehensive. The figures are also very valuable for researchers in this field.

Minor comment:

In Fig1, mTOR is inhibited by TRPML1-derived calcium. Is this OK? The Ref(66) paper may reveal the positive regulation of mTORC1 by lysosomal calcium and calmodulin (PMID: 27787197).

 

RESPONSE.

We thank the reviewer for pointing this out, which was also suggested by the editor. We have modified Figure 1 to indicate activation of TOR by TRPML1 via CaM.

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