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Comparative Mutational Profiling of Hematopoietic Progenitor Cells and Circulating Endothelial Cells (CECs) in Patients with Primary Myelofibrosis
Perspective

A Novel Megakaryocyte Subpopulation Poised to Exert the Function of HSC Niche as Possible Driver of Myelofibrosis

1
Department of Medicine and Surgery, Campus Bio-Medico University, 00128 Rome, Italy
2
Altius Institute for Biomedical Sciences, Seattle, WA 98121, USA
Academic Editor: Françoise Porteu
Cells 2021, 10(12), 3302; https://doi.org/10.3390/cells10123302
Received: 3 November 2021 / Revised: 20 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
Careful morphological investigations, coupled with experimental hematology studies in animal models and in in vitro human cultures, have identified that platelets are released in the circulation by mature megakaryocytes generated by hematopoietic stem cells by giving rise to lineage-restricted progenitor cells and then to morphologically recognizable megakaryocyte precursors, which undergo a process of terminal maturation. Advances in single cell profilings are revolutionizing the process of megakaryocytopoiesis as we have known it up to now. They identify that, in addition to megakaryocytes responsible for producing platelets, hematopoietic stem cells may generate megakaryocytes, which exert either immune functions in the lung or niche functions in organs that undergo tissue repair. Furthermore, it has been discovered that, in addition to hematopoietic stem cells, during ontogeny, and possibly in adult life, megakaryocytes may be generated by a subclass of specialized endothelial precursors. These concepts shed new light on the etiology of myelofibrosis, the most severe of the Philadelphia negative myeloproliferative neoplasms, and possibly other disorders. This perspective will summarize these novel concepts in thrombopoiesis and discuss how they provide a framework to reconciliate some of the puzzling data published so far on the etiology of myelofibrosis and their implications for the therapy of this disease. View Full-Text
Keywords: myelofibrosis; megakaryocytes; thrombopoiesis; transforming growth factor beta (TGF-beta) myelofibrosis; megakaryocytes; thrombopoiesis; transforming growth factor beta (TGF-beta)
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MDPI and ACS Style

Migliaccio, A.R. A Novel Megakaryocyte Subpopulation Poised to Exert the Function of HSC Niche as Possible Driver of Myelofibrosis. Cells 2021, 10, 3302. https://doi.org/10.3390/cells10123302

AMA Style

Migliaccio AR. A Novel Megakaryocyte Subpopulation Poised to Exert the Function of HSC Niche as Possible Driver of Myelofibrosis. Cells. 2021; 10(12):3302. https://doi.org/10.3390/cells10123302

Chicago/Turabian Style

Migliaccio, Anna R. 2021. "A Novel Megakaryocyte Subpopulation Poised to Exert the Function of HSC Niche as Possible Driver of Myelofibrosis" Cells 10, no. 12: 3302. https://doi.org/10.3390/cells10123302

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