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Article

NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies

1
Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland
2
ProMix Center (ProteogenOmix in Medicine) at the Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland
3
Department of Clinical Immunology, Medical University of Warsaw, 02-006 Warsaw, Poland
4
Computational Centre and Institute of Computer Science, University of Białystok, 15-245 Białystok, Poland
5
Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, 02-630 Warsaw, Poland
6
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Marcel J.M. Schaaf and Onno C. Meijer
Cells 2021, 10(11), 3186; https://doi.org/10.3390/cells10113186
Received: 8 October 2021 / Revised: 10 November 2021 / Accepted: 13 November 2021 / Published: 16 November 2021
Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (NR3C1) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the frequency of the NR3C1 SNPs—rs6198, rs41423247 and rs17209237—in 72 IgA nephropathy (IgAN) and 38 membranous nephropathy (MN) patients compared to 175 healthy controls and to correlate the effectiveness of treatment in IgAN and MN groups defined as a reduction of proteinuria <1 g/24 h after 12 months of treatment. Real-time polymerase chain reactions and SNP array-based typing were used. We found significant rs41423247 association with MN (p = 0.026); a significant association of rs17209237 with eGFR reduction after follow-up period in all patients with GNs (p = 0.021) and with the degree of proteinuria after 1 year of therapy in all patients with a glomerulopathy (p = 0.013) and IgAN (p = 0.021); and in the same groups treated with steroids (p = 0.021; p = 0.012). We also observed the association between rs41423247 and IgAN histopathologic findings (p = 0.012). In conclusion, our results indicate that NR3C1 polymorphisms may influence treatment susceptibility and clinical outcome in IgAN and MN. View Full-Text
Keywords: genomics; glucocorticoid receptor; IgA nephropathy; membranous nephropathy; single nucleotide polymorphism genomics; glucocorticoid receptor; IgA nephropathy; membranous nephropathy; single nucleotide polymorphism
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MDPI and ACS Style

Pac, M.; Krata, N.; Moszczuk, B.; Wyczałkowska-Tomasik, A.; Kaleta, B.; Foroncewicz, B.; Rudnicki, W.; Pączek, L.; Mucha, K. NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies. Cells 2021, 10, 3186. https://doi.org/10.3390/cells10113186

AMA Style

Pac M, Krata N, Moszczuk B, Wyczałkowska-Tomasik A, Kaleta B, Foroncewicz B, Rudnicki W, Pączek L, Mucha K. NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies. Cells. 2021; 10(11):3186. https://doi.org/10.3390/cells10113186

Chicago/Turabian Style

Pac, Michał, Natalia Krata, Barbara Moszczuk, Aleksandra Wyczałkowska-Tomasik, Beata Kaleta, Bartosz Foroncewicz, Witold Rudnicki, Leszek Pączek, and Krzysztof Mucha. 2021. "NR3C1 Glucocorticoid Receptor Gene Polymorphisms Are Associated with Membranous and IgA Nephropathies" Cells 10, no. 11: 3186. https://doi.org/10.3390/cells10113186

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