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Review

Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation

Molecular and Translational Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland
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Academic Editor: Ágnes Tantos
Cells 2021, 10(11), 2910; https://doi.org/10.3390/cells10112910
Received: 8 October 2021 / Revised: 22 October 2021 / Accepted: 24 October 2021 / Published: 27 October 2021
Protein binding to the non-coding regions of mRNAs is relatively well characterized and its functionality has been described in many examples. New results obtained by high-throughput methods indicate that binding to the coding sequence (CDS) by RNA-binding proteins is also quite common, but the functions thereof are more obscure. As described in this review, CDS binding has a role in the regulation of mRNA stability, but it has also a more intriguing role in the regulation of translational efficiency. Global approaches, which suggest the significance of CDS binding along with specific examples of CDS-binding RBPs and their modes of action, are outlined here, pointing to the existence of a relatively less-known regulatory network controlling mRNA stability and translation on yet another level. View Full-Text
Keywords: RNA-binding proteins; coding sequence; mammalian post-transcriptional gene expression RNA-binding proteins; coding sequence; mammalian post-transcriptional gene expression
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MDPI and ACS Style

Grzybowska, E.A.; Wakula, M. Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation. Cells 2021, 10, 2910. https://doi.org/10.3390/cells10112910

AMA Style

Grzybowska EA, Wakula M. Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation. Cells. 2021; 10(11):2910. https://doi.org/10.3390/cells10112910

Chicago/Turabian Style

Grzybowska, Ewa A., and Maciej Wakula. 2021. "Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation" Cells 10, no. 11: 2910. https://doi.org/10.3390/cells10112910

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