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Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

by 1,2,†, 1,3,†, 4, 1,* and 1,2,5,6,*
1
Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
2
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA
3
Baylor College of Medicine, Houston, TX 77030, USA
4
Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
5
Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
6
Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Miguel Fidalgo, Ana Sevilla and Francesca Aguilo
Cells 2021, 10(11), 2823; https://doi.org/10.3390/cells10112823
Received: 20 August 2021 / Revised: 5 October 2021 / Accepted: 15 October 2021 / Published: 21 October 2021
The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the cardiovascular system, causing adverse and sometimes fatal side effects that negate the chemotherapeutic benefits. The prevalence and severity of chemotherapy-induced cardiotoxicity warrants a deeper investigation of the mechanisms and implicating factors in this phenomenon, and a consolidation of scientific efforts to develop mitigating strategies. Aiding these efforts is the emergence of induced pluripotent stem cells (iPSCs) in recent years, which has allowed for the generation of iPSC-derived cardiomyocytes (iPSC-CMs): a human-based, patient-derived, and genetically variable platform that can be applied to the study of chemotherapy-induced cardiotoxicity and beyond. After surveying chemotherapy-induced cardiotoxicity and the associated chemotherapeutic agents, we discuss the use of iPSC-CMs in cardiotoxicity modeling, drug screening, and other potential applications. Improvements to the iPSC-CM platform, such as the development of more adult-like cardiomyocytes and ongoing advances in biotechnology, will only enhance the utility of iPSC-CMs in both basic science and clinical applications. View Full-Text
Keywords: stem cell; disease model; induced pluripotency; reprogramming; differentiation; chemotherapy; cancer; cardiotoxicity; personalized medicine; pharmacogenomics stem cell; disease model; induced pluripotency; reprogramming; differentiation; chemotherapy; cancer; cardiotoxicity; personalized medicine; pharmacogenomics
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MDPI and ACS Style

Huang, M.-F.; Pang, L.K.; Chen, Y.-H.; Zhao, R.; Lee, D.-F. Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells 2021, 10, 2823. https://doi.org/10.3390/cells10112823

AMA Style

Huang M-F, Pang LK, Chen Y-H, Zhao R, Lee D-F. Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells. 2021; 10(11):2823. https://doi.org/10.3390/cells10112823

Chicago/Turabian Style

Huang, Mo-Fan, Lon K. Pang, Yi-Hung Chen, Ruiying Zhao, and Dung-Fang Lee. 2021. "Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes" Cells 10, no. 11: 2823. https://doi.org/10.3390/cells10112823

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