Unzipping the Secrets of Amyloid Disassembly by the Human Disaggregase
Abstract
:1. Introduction: Neurodegeneration and Amyloid Deposition
2. Synucleinopathies and α-Synuclein Amyloid Formation
3. Disaggregation of α-Synuclein Amyloids by Molecular Chaperones
3.1. Hsp104 Disaggregase
3.2. The Human Hsp70-Based Disaggregase System
3.3. Models for the Disassembly of Amyloids by the Human Disaggregase
4. Expanding the Human Disaggregase Activity
4.1. Chaperone-Mediated Disassembly of Other Amyloidogenic Proteins
4.2. Impact of Amyloid Polymorphism in Chaperone Activity
5. Human Disaggregase in Amyloid Toxicity and Propagation: Friend and Foe
6. Conclusions and Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Franco, A.; Velasco-Carneros, L.; Alvarez, N.; Orozco, N.; Moro, F.; Prado, A.; Muga, A. Unzipping the Secrets of Amyloid Disassembly by the Human Disaggregase. Cells 2021, 10, 2745. https://doi.org/10.3390/cells10102745
Franco A, Velasco-Carneros L, Alvarez N, Orozco N, Moro F, Prado A, Muga A. Unzipping the Secrets of Amyloid Disassembly by the Human Disaggregase. Cells. 2021; 10(10):2745. https://doi.org/10.3390/cells10102745
Chicago/Turabian StyleFranco, Aitor, Lorea Velasco-Carneros, Naiara Alvarez, Natalia Orozco, Fernando Moro, Adelina Prado, and Arturo Muga. 2021. "Unzipping the Secrets of Amyloid Disassembly by the Human Disaggregase" Cells 10, no. 10: 2745. https://doi.org/10.3390/cells10102745