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Expression of CD38 in Mast Cells: Cytological and Histotopographic Features

Research and Educational Resource Center for Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis Innovative Technologies, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
Research Institute of Experimental Biology and Medicine, Burdenko Voronezh State Medical University, 394036 Voronezh, Russia
Institute for Hematopathology, Fangdieckstr. 75a, 22547 Hamburg, Germany
Author to whom correspondence should be addressed.
Academic Editors: Pavel Dráber, Fabio Malavasi, Aneel Paulus and Claudio Cerchione
Cells 2021, 10(10), 2511;
Received: 18 July 2021 / Revised: 7 September 2021 / Accepted: 19 September 2021 / Published: 22 September 2021
The biological significance of the CD38 molecule goes beyond metabolic, enzymatic, and proliferative functions. CD38 possesses the functions of an exoenzyme and receptor, and is actively involved in the mechanisms of adhesion, migration, intercellular signaling, formation of immune synapses, and modulation of the activity of a wide range of immune and non-immune cells. The aim of this study was the immunohistochemical assessment of the cytological and histotopographic characteristics of CD38 expression in mast cells. CD38 expression was found in a minority of the mast cell population. It is characterized by wide variability from low to high levels. The intensity of CD38 expression in mast cells has organ-specific features and depends on the development of pathological processes in a specific tissue microenvironment. The mechanisms of intercellular interaction between mast cells and CD38+ cells foster new understanding of the protumorigenic or antitumor potential of tryptase. View Full-Text
Keywords: CD38; mast cells; tryptase; secretion CD38; mast cells; tryptase; secretion
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MDPI and ACS Style

Atiakshin, D.; Samoilova, V.; Buchwalow, I.; Tiemann, M. Expression of CD38 in Mast Cells: Cytological and Histotopographic Features. Cells 2021, 10, 2511.

AMA Style

Atiakshin D, Samoilova V, Buchwalow I, Tiemann M. Expression of CD38 in Mast Cells: Cytological and Histotopographic Features. Cells. 2021; 10(10):2511.

Chicago/Turabian Style

Atiakshin, Dmitri, Vera Samoilova, Igor Buchwalow, and Markus Tiemann. 2021. "Expression of CD38 in Mast Cells: Cytological and Histotopographic Features" Cells 10, no. 10: 2511.

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