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Pan-Cancer Molecular Patterns and Biological Implications Associated with a Tumor-Specific Molecular Signature
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Tumor Suppressors Having Oncogenic Functions: The Double Agents

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Cancer Biology and Inflammatory Disorder Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology (CSIR-IICB), TRUE Campus, CN-6, Sector–V, Salt Lake, Kolkata-700091 & 4, Raja S.C. Mullick Road, Jadavpur, Kolkata-700032, India
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Department of Microbiology, Dhruba Chand Halder College, Dakshin Barasat, South 24 Paraganas, West Bengal PIN-743372, India
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 46; https://doi.org/10.3390/cells10010046
Received: 27 November 2020 / Revised: 23 December 2020 / Accepted: 25 December 2020 / Published: 31 December 2020
Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor suppressor genes are recessive in nature, anti-proliferative, and frequently found inactivated or mutated in cancers. However, extensive research over the last few years have elucidated that certain tumor suppressor genes do not conform to these standard definitions and might act as “double agents”, playing contrasting roles in vivo in cells, where either due to haploinsufficiency, epigenetic hypermethylation, or due to involvement with multiple genetic and oncogenic events, they play an enhanced proliferative role and facilitate the pathogenesis of cancer. This review discusses and highlights some of these exceptions; the genetic events, cellular contexts, and mechanisms by which four important tumor suppressors—pRb, PTEN, FOXO, and PML display their oncogenic potentials and pro-survival traits in cancer. View Full-Text
Keywords: tumor suppressor genes; Rb; PTEN; FOXO; PML; cancer tumor suppressor genes; Rb; PTEN; FOXO; PML; cancer
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MDPI and ACS Style

Datta, N.; Chakraborty, S.; Basu, M.; Ghosh, M.K. Tumor Suppressors Having Oncogenic Functions: The Double Agents. Cells 2021, 10, 46. https://doi.org/10.3390/cells10010046

AMA Style

Datta N, Chakraborty S, Basu M, Ghosh MK. Tumor Suppressors Having Oncogenic Functions: The Double Agents. Cells. 2021; 10(1):46. https://doi.org/10.3390/cells10010046

Chicago/Turabian Style

Datta, Neerajana, Shrabastee Chakraborty, Malini Basu, and Mrinal K. Ghosh. 2021. "Tumor Suppressors Having Oncogenic Functions: The Double Agents" Cells 10, no. 1: 46. https://doi.org/10.3390/cells10010046

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