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Open AccessArticle

Autophagy Involvement in the Postnatal Development of the Rat Retina

1
Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Eugeniavägen 12, 17164 Solna, Sweden
2
Department of Biology, University of Pisa, Via San Zeno 31, 56127 Pisa, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to the present work.
Cells 2021, 10(1), 177; https://doi.org/10.3390/cells10010177
Received: 18 December 2020 / Revised: 13 January 2021 / Accepted: 14 January 2021 / Published: 17 January 2021
(This article belongs to the Special Issue The Retina in Health and Disease)
During retinal development, a physiologic hypoxia stimulates endothelial cell proliferation. The hypoxic milieu warrants retina vascularization and promotes the activation of several mechanisms aimed to ensure homeostasis and energy balance of both endothelial and retinal cells. Autophagy is an evolutionarily conserved catabolic system that contributes to cellular adaptation to a variety of environmental changes and stresses. In association with the physiologic hypoxia, autophagy plays a crucial role during development. Autophagy expression profile was evaluated in the developing retina from birth to post-natal day 18 of rat pups, using qPCR, western blotting and immunostaining methodologies. The rat post-partum developing retina displayed increased active autophagy during the first postnatal days, correlating to the hypoxic phase. In latter stages of development, rat retinal autophagy decreases, reaching a normalization between post-natal days 14-18, when the retina is fully vascularized and mature. Collectively, the present study elaborates on the link between hypoxia and autophagy, and contributes to further elucidate the role of autophagy during retinal development. View Full-Text
Keywords: eye; retina; development; vascularization; hypoxia; autophagy eye; retina; development; vascularization; hypoxia; autophagy
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MDPI and ACS Style

Pesce, N.A.; Canovai, A.; Lardner, E.; Cammalleri, M.; Kvanta, A.; André, H.; Dal Monte, M. Autophagy Involvement in the Postnatal Development of the Rat Retina. Cells 2021, 10, 177. https://doi.org/10.3390/cells10010177

AMA Style

Pesce NA, Canovai A, Lardner E, Cammalleri M, Kvanta A, André H, Dal Monte M. Autophagy Involvement in the Postnatal Development of the Rat Retina. Cells. 2021; 10(1):177. https://doi.org/10.3390/cells10010177

Chicago/Turabian Style

Pesce, Noemi A.; Canovai, Alessio; Lardner, Emma; Cammalleri, Maurizio; Kvanta, Anders; André, Helder; Dal Monte, Massimo. 2021. "Autophagy Involvement in the Postnatal Development of the Rat Retina" Cells 10, no. 1: 177. https://doi.org/10.3390/cells10010177

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