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Open AccessReview

PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response

1
Institute of Biostructures and Bioimaging, IBB, CNR, 80134 Naples, Italy
2
Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, 00168 Rome, Italy
3
Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie—Sezione di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
4
Mater Olbia Hospital, 07026 Olbia, Italy
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 161; https://doi.org/10.3390/cells10010161
Received: 17 November 2020 / Revised: 4 January 2021 / Accepted: 12 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Molecular Immunology in Bacterial Vaccine Discovery)
PE_PGRS proteins are surface antigens of Mycobacterium tuberculosis (Mtb) and a few other pathogenic mycobacteria. The PE_PGRS33 protein is among the most studied PE_PGRSs. It is known that the PE domain of PE_PGRS33 is required for the protein translocation through the mycobacterial cell wall, where the PGRS domain remains available for interaction with host receptors. Interaction with Toll like receptor 2 (TLR2) promotes secretion of inflammatory chemokines and cytokines, which are key in the immunopathogenesis of tuberculosis (TB). In this review, we briefly address some key challenges in the development of a TB vaccine and attempt to provide a rationale for the development of new vaccines aimed at fostering a humoral response against Mtb. Using PE_PGRS33 as a model for a surface-exposed antigen, we exploit the availability of current structural data using homology modeling to gather insights on the PGRS domain features. Our study suggests that the PGRS domain of PE_PGRS33 exposes four PGII sandwiches on the outer surface, which, we propose, are directly involved through their loops in the interactions with the host receptors and, as such, are promising targets for a vaccination strategy aimed at inducing a humoral response. View Full-Text
Keywords: vaccine; protein structure; tuberculosis; infectious disease vaccine; protein structure; tuberculosis; infectious disease
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MDPI and ACS Style

Kramarska, E.; Squeglia, F.; De Maio, F.; Delogu, G.; Berisio, R. PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response. Cells 2021, 10, 161. https://doi.org/10.3390/cells10010161

AMA Style

Kramarska E, Squeglia F, De Maio F, Delogu G, Berisio R. PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response. Cells. 2021; 10(1):161. https://doi.org/10.3390/cells10010161

Chicago/Turabian Style

Kramarska, Eliza; Squeglia, Flavia; De Maio, Flavio; Delogu, Giovanni; Berisio, Rita. 2021. "PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response" Cells 10, no. 1: 161. https://doi.org/10.3390/cells10010161

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