Next Article in Journal
The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention
Next Article in Special Issue
Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications
Previous Article in Journal
Calcium Signalling in Alzheimer’s Disease: From Pathophysiological Regulation to Therapeutic Approaches
Review

Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models

Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland
Cells 2021, 10(1), 141; https://doi.org/10.3390/cells10010141
Received: 30 November 2020 / Revised: 7 January 2021 / Accepted: 7 January 2021 / Published: 12 January 2021
(This article belongs to the Special Issue Hypoxia and Cancer: Mechanisms of Resistance and Metastasis)
Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects cancer progression, metastasis and metabolism. Oxygen induces both proteomic and genomic changes within tumor cells, which cause many alternations in the tumor microenvironment (TME). This review defines current knowledge in the field of tumor hypoxia in non-small cell lung cancer (NSCLC), including biology, biomarkers, in vitro and in vivo studies and also hypoxia imaging and detection. While classic two-dimensional (2D) in vitro research models reveal some hypoxia dependent manifestations, three-dimensional (3D) cell culture models more accurately replicate the hypoxic TME. In this study, a systematic review of the current NSCLC 3D models that have been able to mimic the hypoxic TME is presented. The multicellular tumor spheroid, organoids, scaffolds, microfluidic devices and 3D bioprinting currently being utilized in NSCLC hypoxia studies are reviewed. Additionally, the utilization of 3D in vitro models for exploring biological and therapeutic parameters in the future is described. View Full-Text
Keywords: lung cancer; hypoxia; tumor microenvironment; three-dimensional; in vitro models lung cancer; hypoxia; tumor microenvironment; three-dimensional; in vitro models
Show Figures

Figure 1

MDPI and ACS Style

Ziółkowska-Suchanek, I. Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models. Cells 2021, 10, 141. https://doi.org/10.3390/cells10010141

AMA Style

Ziółkowska-Suchanek I. Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models. Cells. 2021; 10(1):141. https://doi.org/10.3390/cells10010141

Chicago/Turabian Style

Ziółkowska-Suchanek, Iwona. 2021. "Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models" Cells 10, no. 1: 141. https://doi.org/10.3390/cells10010141

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop