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Autophagy and Cancer

IGM-CNR, Via Abbiategrasso 207, Pavia 27100, Italy
UTPL, Loja 1101608, Ecuador
Author to whom correspondence should be addressed.
Cells 2012, 1(3), 520-534;
Received: 14 June 2012 / Revised: 28 June 2012 / Accepted: 30 July 2012 / Published: 13 August 2012
(This article belongs to the Special Issue Autophagy)
PDF [1173 KB, uploaded 13 August 2012]


Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks to the energetic supply provided by organelle degradation typically driven by autophagy following a stepwise pathway. The main actors of the autophagic machinery as well as the features shared with apoptosis will be described. Special attention will be paid to the effects of autophagy manipulation. View Full-Text
Keywords: apoptosis; autophagy; cancer; cell death apoptosis; autophagy; cancer; cell death

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Aredia, F.; Guamán Ortiz, L.M.; Giansanti, V.; Scovassi, A.I. Autophagy and Cancer. Cells 2012, 1, 520-534.

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