Next Article in Journal
Potassium Iodide-Functionalized Polyaniline Nanothin Film Chemiresistor for Ultrasensitive Ozone Gas Sensing
Previous Article in Journal
Correlation of Microstructure, Rheological and Morphological Characteristics of Synthesized Polypropylene (PP) Reactor Blends Using Homogeneous Binary Metallocene Catalyst
Previous Article in Special Issue
A Comprehensive Systematic Study on Thermoresponsive Gels: Beyond the Common Architectures of Linear Terpolymers
Communication

Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers

Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Wei Min Huang
Polymers 2017, 9(3), 79; https://doi.org/10.3390/polym9030079
Received: 6 January 2017 / Revised: 13 February 2017 / Accepted: 21 February 2017 / Published: 24 February 2017
(This article belongs to the Special Issue Young Talents in Polymer Science)
The realization of gene therapy relies on the development of delivery vectors with high efficiency and biocompatibility. With a multitude of structures accessible, the core challenge is precisely tuning vector structure to probe and optimize structure–property relationships. Employing a modular strategy, two pairs of cationic polymers based on the trisaminocyclopropenium (TAC) ion were synthesized where the substituents differ in the degree of alkyl chain branching. All TAC-based polymers exhibited higher transfection efficiencies than the untreated controls, with variable in vitro toxicities. Considering both cytotoxicity and transfection efficacy, an optimal nonviral vector was identified. Our studies highlight the importance of exercising precise control over polymer structure, both in terms of backbone identity and substituent nature, and the necessity of a robust, modular platform from which to study them. View Full-Text
Keywords: gene delivery; polyelectrolyte; nonviral vectors; structure-property relationships gene delivery; polyelectrolyte; nonviral vectors; structure-property relationships
Show Figures

Graphical abstract

MDPI and ACS Style

Brucks, S.D.; Freyer, J.L.; Lambert, T.H.; Campos, L.M. Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers. Polymers 2017, 9, 79. https://doi.org/10.3390/polym9030079

AMA Style

Brucks SD, Freyer JL, Lambert TH, Campos LM. Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers. Polymers. 2017; 9(3):79. https://doi.org/10.3390/polym9030079

Chicago/Turabian Style

Brucks, Spencer D., Jessica L. Freyer, Tristan H. Lambert, and Luis M. Campos. 2017. "Influence of Substituent Chain Branching on the Transfection Efficacy of Cyclopropenium-Based Polymers" Polymers 9, no. 3: 79. https://doi.org/10.3390/polym9030079

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop