Next Article in Journal
Microwave Assisted Preparation of Antimicrobial Chitosan with Guanidine Oligomers and Its Application in Hygiene Paper Products
Next Article in Special Issue
Biomimetically Reinforced Polyvinyl Alcohol-Based Hybrid Scaffolds for Cartilage Tissue Engineering
Previous Article in Journal
Silane Cross-Linked Sulfonted Poly(Ether Ketone/Ether Benzimidazole)s for Fuel Cell Applications
Previous Article in Special Issue
Recent Advances in Antimicrobial Hydrogels Containing Metal Ions and Metals/Metal Oxide Nanoparticles
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Polymers 2017, 9(12), 639; https://doi.org/10.3390/polym9120639

Transparent Low Molecular Weight Poly(Ethylene Glycol) Diacrylate-Based Hydrogels as Film Media for Photoswitchable Drugs

1
Leibniz-Institute of Surface Modification, Permoserstraβe 15, 04318 Leipzig, Germany
2
Key Center for Polymers and Colloids, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia
Both authors contributed equally to this publication.
*
Author to whom correspondence should be addressed.
Received: 10 October 2017 / Revised: 16 November 2017 / Accepted: 18 November 2017 / Published: 23 November 2017
(This article belongs to the Special Issue Hydrogels in Tissue Engineering and Regenerative Medicine)
Full-Text   |   PDF [2583 KB, uploaded 23 November 2017]   |  

Abstract

Hydrogels have shown a great potential as materials for drug delivery systems thanks to their usually excellent bio-compatibility and their ability to trap water-soluble organic molecules in a porous network. In this study, poly(ethylene glycol)-based hydrogels containing a model dye were synthesized by ultraviolet (UV-A) photopolymerization of low-molecular weight macro-monomers and the material properties (dye release ability, transparency, morphology, and polymerization kinetics) were studied. Real-time infrared measurements revealed that the photopolymerization of the materials was strongly limited when the dye was added to the uncured formulation. Consequently, the procedure was adapted to allow for the formation of sufficiently cured gels that are able to capture and later on to release dye molecules in phosphate-buffered saline solution within a few hours. Due to the transparency of the materials in the 400–800 nm range, the hydrogels are suitable for the loading and excitation of photoactive molecules. These can be uptaken by and released from the polymer matrix. Therefore, such materials may find applications as cheap and tailored materials in photodynamic therapy (i.e., light-induced treatment of skin infections by bacteria, fungi, and viruses using photoactive drugs). View Full-Text
Keywords: hydrogels; drug release; photopolymerization; photosensitizer; poly(ethylene glycol) diacrylate; photodynamic therapy hydrogels; drug release; photopolymerization; photosensitizer; poly(ethylene glycol) diacrylate; photodynamic therapy
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Pelras, T.; Glass, S.; Scherzer, T.; Elsner, C.; Schulze, A.; Abel, B. Transparent Low Molecular Weight Poly(Ethylene Glycol) Diacrylate-Based Hydrogels as Film Media for Photoswitchable Drugs. Polymers 2017, 9, 639.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top