Nitric Oxide Releasing Polymeric Coatings for the Prevention of Biofilm Formation
by
George Fleming 1
, Jenny Aveyard 1, Joanne L. Fothergill 2, Fiona McBride 3, Rasmita Raval 3 and Raechelle A. D’Sa 1,*
George Fleming 1, Jenny Aveyard 1, Joanne L. Fothergill 2, Fiona McBride 3, Rasmita Raval 3 and Raechelle A. D’Sa 1,*
1
Department of Mechanical, Materials and Aerospace Engineering, University of Liverpool, Liverpool L69 3GH, UK
2
Institute of Infection and Global Health, University of Liverpool, 8 West Derby Street, Liverpool L69 7B3, UK
3
The Open Innovation Hub for Antimicrobial Surfaces, Surface Science Research Centre, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK
*
Author to whom correspondence should be addressed.
Polymers 2017, 9(11), 601; https://doi.org/10.3390/polym9110601
Received: 31 August 2017 / Revised: 30 October 2017 / Accepted: 8 November 2017 / Published: 11 November 2017
(This article belongs to the Special Issue Advance of Polymers Applied to Biomedical Applications: Biointerface)
The ability of nitric oxide (NO)-releasing polymer coatings to prevent biofilm formation is described. NO-releasing coatings on (poly(ethylene terephthalate) (PET) and silicone elastomer (SE)) were fabricated using aminosilane precursors. Pristine PET and SE were oxygen plasma treated, followed by immobilisation of two aminosilane molecules: N-(3-(trimethoxysilyl)propyl)diethylenetriamine (DET3) and N-(3-trimethoxysilyl)propyl)aniline (PTMSPA). N-diazeniumdiolate nitric oxide donors were formed at the secondary amine sites on the aminosilane molecules producing NO-releasing polymeric coatings. The NO payload and release were controlled by the aminosilane precursor, as DET3 has two secondary amine sites and PTMSPA only one. The antibacterial efficacy of these coatings was tested using a clinical isolate of Pseudomonas aeruginosa (PA14). All NO-releasing coatings in this study were shown to significantly reduce P. aeruginosa adhesion over 24 h with the efficacy being a function of the aminosilane modification and the underlying substrate. These NO-releasing polymers demonstrate the potential and utility of this facile coating technique for preventing biofilms for indwelling medical devices.
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Keywords:
nitric oxide donors; N-diazeniumdiolates; drug release; antimicrobial surfaces; biofilm prevention
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Fleming, G.; Aveyard, J.; Fothergill, J.L.; McBride, F.; Raval, R.; D’Sa, R.A. Nitric Oxide Releasing Polymeric Coatings for the Prevention of Biofilm Formation. Polymers 2017, 9, 601.
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