Next Article in Journal
Restoration of Impaired Metabolic Energy Balance (ATP Pool) and Tube Formation Potential of Endothelial Cells under “high glucose”, Diabetic Conditions by the Bioinorganic Polymer Polyphosphate
Next Article in Special Issue
Long Range Polymer Chain Dynamics of Highly Flexible Polysiloxane in Solution Probed by Pyrene Excimer Fluorescence
Previous Article in Journal
Ultra-Broadband THz Antireflective Coating with Polymer Composites
Previous Article in Special Issue
Poly(tris(4-carbazoyl-9-ylphenyl)amine)/Three Poly(3,4-ethylenedioxythiophene) Derivatives in Complementary High-Contrast Electrochromic Devices
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Polymers 2017, 9(11), 576;

A Cationic Smart Copolymer for DNA Binding

CQFM—Centro de Química-Física Molecular and IN—Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal
Author to whom correspondence should be addressed.
Received: 6 October 2017 / Revised: 25 October 2017 / Accepted: 2 November 2017 / Published: 4 November 2017
(This article belongs to the Special Issue Polymer Characterization)
Full-Text   |   PDF [4069 KB, uploaded 4 November 2017]   |  


A new block copolymer with a temperature-responsive block and a cationic block was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization, with good control of its size and composition. The first block is composed by di(ethylene glycol) methyl ether methacrylate (DEGMA) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA), with the ratio DEGMA/OEGMA being used to choose the volume phase transition temperature of the polymer in water, tunable from ca. 25 to above 90 °C. The second block, of trimethyl-2-methacroyloxyethylammonium chloride (TMEC), is positively charged at physiological pH values and is used for DNA binding. The coacervate complexes between the block copolymer and a model single strand DNA are characterized by fluorescence correlation spectroscopy and fluorescence spectroscopy. The new materials offer good prospects for biomedical application, for example in controlled gene delivery. View Full-Text
Keywords: block copolymer; stimuli responsive polymer; DNA; fluorescence; FCS block copolymer; stimuli responsive polymer; DNA; fluorescence; FCS

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Ribeiro, T.; Santiago, A.M.; Gaspar Martinho, J.M.; Farinha, J.P. A Cationic Smart Copolymer for DNA Binding. Polymers 2017, 9, 576.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top