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Polymers 2017, 9(10), 521; https://doi.org/10.3390/polym9100521

(Cryo)Transmission Electron Microscopy of Phospholipid Model Membranes Interacting with Amphiphilic and Polyphilic Molecules

1
Institute of Chemistry, Martin Luther University Halle-Wittenberg, D-06120 Halle (Saale), Germany
2
Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, D-06120 Halle (Saale), Germany
*
Author to whom correspondence should be addressed.
Received: 28 September 2017 / Revised: 12 October 2017 / Accepted: 13 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue From Amphiphilic to Polyphilic Polymers)
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Abstract

Lipid membranes can incorporate amphiphilic or polyphilic molecules leading to specific functionalities and to adaptable properties of the lipid bilayer host. The insertion of guest molecules into membranes frequently induces changes in the shape of the lipid matrix that can be visualized by transmission electron microscopy (TEM) techniques. Here, we review the use of stained and vitrified specimens in (cryo)TEM to characterize the morphology of amphiphilic and polyphilic molecules upon insertion into phospholipid model membranes. Special emphasis is placed on the impact of novel synthetic amphiphilic and polyphilic bolalipids and polymers on membrane integrity and shape stability. View Full-Text
Keywords: lipids; fluorinated amphiphiles; bolalipids; polyphiles; (cryo)transmission electron microscopy lipids; fluorinated amphiphiles; bolalipids; polyphiles; (cryo)transmission electron microscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Meister, A.; Blume, A. (Cryo)Transmission Electron Microscopy of Phospholipid Model Membranes Interacting with Amphiphilic and Polyphilic Molecules. Polymers 2017, 9, 521.

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