Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts

Girard, Jérôme; Joset, Nathalie; Crochet, Aurélien; Tan, Milène; Holzheu, Anja; Brunetto, Priscilla S.; Fromm, Katharina M.

doi:10.3390/polym8060208

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Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts

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Priscilla S. Brunetto

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Katharina M. Fromm

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Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland

Fribourg Center for Nanomaterials, FriMat, Department of Physics, University of Fribourg, Chemin du Musée 3, 1700 Fribourg, Switzerland

Author to whom correspondence should be addressed.

Academic Editor: Jianxun Ding

Polymers 2016, 8(6), 208; https://doi.org/10.3390/polym8060208

Received: 15 March 2016 / Revised: 13 May 2016 / Accepted: 19 May 2016 / Published: 30 May 2016

(This article belongs to the Special Issue Functional Polymers for Medical Applications)

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Abstract

Polyether ether ketone (PEEK) is a well-known polymer used for implants and devices, especially spinal ones. To overcome the biomaterial related infection risks, 4-4′-difluorobenzophenone, the famous PEEK monomer, was modified in order to introduce binding sites for silver ions, which are well known for their antimicrobial activity. The complexation of these new monomers with different silver salts was studied. Crystal structures of different intermediates were obtained with a linear coordination between two pyridine groups and the silver ions in all cases. The mechanical and thermal properties of different new polymers were characterized. The synthesized PEEKN5 polymers showed similar properties than the PEEK ones whereas the PEEKN7 polymers showed similar thermal properties but the mechanical properties are not as good as the ones of PEEK. To improve these properties, these polymers were complexed with silver nitrate in order to “cross-link” with silver ions. The presence of ionic silver in the polymer was then confirmed by thermogravimetric analysis (TGA) and X-ray powder diffraction (XRPD). Finally, a silver-based antimicrobial compound was successfully coated on the surface of PEEKN5. View Full-Text

Keywords: PEEK; antimicrobial polymer coating; silver coordination polymer

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MDPI and ACS Style

Girard, J.; Joset, N.; Crochet, A.; Tan, M.; Holzheu, A.; Brunetto, P.S.; Fromm, K.M. Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts. Polymers 2016, 8, 208. https://doi.org/10.3390/polym8060208

AMA Style

Girard J, Joset N, Crochet A, Tan M, Holzheu A, Brunetto PS, Fromm KM. Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts. Polymers. 2016; 8(6):208. https://doi.org/10.3390/polym8060208

Chicago/Turabian Style

Girard, Jérôme, Nathalie Joset, Aurélien Crochet, Milène Tan, Anja Holzheu, Priscilla S. Brunetto, and Katharina M. Fromm. 2016. "Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts" Polymers 8, no. 6: 208. https://doi.org/10.3390/polym8060208

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Synthesis of New Polyether Ether Ketone Derivatives with Silver Binding Site and Coordination Compounds of Their Monomers with Different Silver Salts

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