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Polymers 2016, 8(2), 56;

pH-Responsive Intra- and Inter-Molecularly Micelle Formation of Anionic Diblock Copolymer in Water

Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan
Faculty of Engineering, Fukui University of Technology, 6-3-1 Gakuen, Fukui 910-8505, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Christine Wandrey
Received: 25 January 2016 / Revised: 14 February 2016 / Accepted: 16 February 2016 / Published: 19 February 2016
(This article belongs to the Collection Polyelectrolytes)
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Poly(sodium2-(acrylamido)-2-methylpropanesulfonate)-block-poly(sodium11-(acrylamido)undecanoate) (PAMPS–PAaU) was synthesized via reversible addition-fragmentation chain transfer (RAFT)-controlled radical polymerization. The “living” polymerization of PAaU was evidenced by the fact that the molecular weight distribution was narrow (Mw/Mn = 1.23). The pH-induced association behavior of PAMPS–PAaU in 0.1 M NaCl aqueous solutions as a function of solution pH was investigated by 1H NMR spin-spin relaxation time, dynamic light scattering (DLS), static light scattering (SLS), and fluorescence probe techniques. These results indicated that PAMPS–PAaU formed polymer micelles in 0.1 M NaCl aqueous solutions at pH < 9. At pH = 8–9, the polymer formed the micelles intramolecularly due to hydrophobic self-association of the PAaU block within the single polymer chain. On the other hand, at pH < 8, micellization occurred intermolecularly to form polymer micelles comprising hydrophobic PAaU cores and hydrophilic PAMPS shells. View Full-Text
Keywords: block copolymer; micelles; RAFT polymerization; water-soluble polymer; pH-responsive block copolymer; micelles; RAFT polymerization; water-soluble polymer; pH-responsive

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Mizusaki, M.; Shimada, Y.; Morishima, Y.; Yusa, S.-I. pH-Responsive Intra- and Inter-Molecularly Micelle Formation of Anionic Diblock Copolymer in Water. Polymers 2016, 8, 56.

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