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Polymers
Volume 17
Issue 10
10.3390/polym17101307
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Synthesis and Characterization of a Novel Cassava Starch-Based Scaffold Biofunctionalized with Decellularized Extracellular Matrix and Isosorbide Dinitrate

by
Samantha Dení Cabo-Araoz
1,2,
Bernardino Isaac Cerda-Cristerna
3,
Diana María Escobar-García
1,
José Manuel Gutiérrez-Hernández
1,
Mariana Gutiérrez-Sánchez
4,
Amaury Pozos-Guillén
1,2,* and
Héctor Flores
1,2
1
Basic Science Laboratory, Faculty of Dentistry, University of San Luis Potosí, Av. Dr. Manuel Nava 2, San Luis Potosí 78290, SLP, Mexico
2
Doctorado Institucional en Ingeniería y Ciencia de Materiales, Faculty of Dentistry, University of San Luis Potosí, Av. Dr. Manuel Nava 2, San Luis Potosí 78290, SLP, Mexico
3
Faculty of Dentistry, Orizaba-Córdoba, University of Veracruz, Abasolo Sur S/N, Tenango de Río Blanco 94732, VE, Mexico
4
Endodontics Postgraduate Program, Faculty of Dentistry, University of San Luis Potosí, Av. Dr. Manuel Nava 2, San Luis Potosí 78290, SLP, Mexico
*
Author to whom correspondence should be addressed.
Polymers 2025, 17(10), 1307; https://doi.org/10.3390/polym17101307 (registering DOI)
Submission received: 24 April 2025 / Revised: 8 May 2025 / Accepted: 8 May 2025 / Published: 10 May 2025
(This article belongs to the Section Polymer Analysis and Characterization)
Versions Notes

Abstract

This study aimed to synthesize and characterize cassava starch-based (S) scaffolds functionalized with decellularized extracellular matrix (dECM) and isosorbide dinitrate (ISDN) for wound healing. The scaffolds were synthesized via the casting method and evaluated for physicochemical, mechanical, and morphological properties, as well as ISDN release and hemocompatibility. Swelling and degradation tests revealed a biphasic behavior, with high water absorption followed by controlled degradation. The ISDN release followed a biphasic pattern, fitting the Korsmeyer–Peppas model. Hemolysis tests confirmed biocompatibility, with hemolysis levels below 2%. Among the formulations, the scaffold containing 12.5% ECM and 40 mg ISDN exhibited optimal mechanical stability, controlled drug release, and biocompatibility. These findings suggest that starch/ECM/ISDN scaffolds hold potential for wound healing applications. Further studies should focus on in vivo evaluation and cytotoxicity assessments to confirm their clinical applicability.
Keywords: biopolymeric system; starch; ECD; ISDN biopolymeric system; starch; ECD; ISDN

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MDPI and ACS Style

Cabo-Araoz, S.D.; Cerda-Cristerna, B.I.; Escobar-García, D.M.; Gutiérrez-Hernández, J.M.; Gutiérrez-Sánchez, M.; Pozos-Guillén, A.; Flores, H. Synthesis and Characterization of a Novel Cassava Starch-Based Scaffold Biofunctionalized with Decellularized Extracellular Matrix and Isosorbide Dinitrate. Polymers 2025, 17, 1307. https://doi.org/10.3390/polym17101307

AMA Style

Cabo-Araoz SD, Cerda-Cristerna BI, Escobar-García DM, Gutiérrez-Hernández JM, Gutiérrez-Sánchez M, Pozos-Guillén A, Flores H. Synthesis and Characterization of a Novel Cassava Starch-Based Scaffold Biofunctionalized with Decellularized Extracellular Matrix and Isosorbide Dinitrate. Polymers. 2025; 17(10):1307. https://doi.org/10.3390/polym17101307

Chicago/Turabian Style

Cabo-Araoz, Samantha Dení, Bernardino Isaac Cerda-Cristerna, Diana María Escobar-García, José Manuel Gutiérrez-Hernández, Mariana Gutiérrez-Sánchez, Amaury Pozos-Guillén, and Héctor Flores. 2025. "Synthesis and Characterization of a Novel Cassava Starch-Based Scaffold Biofunctionalized with Decellularized Extracellular Matrix and Isosorbide Dinitrate" Polymers 17, no. 10: 1307. https://doi.org/10.3390/polym17101307

APA Style

Cabo-Araoz, S. D., Cerda-Cristerna, B. I., Escobar-García, D. M., Gutiérrez-Hernández, J. M., Gutiérrez-Sánchez, M., Pozos-Guillén, A., & Flores, H. (2025). Synthesis and Characterization of a Novel Cassava Starch-Based Scaffold Biofunctionalized with Decellularized Extracellular Matrix and Isosorbide Dinitrate. Polymers, 17(10), 1307. https://doi.org/10.3390/polym17101307

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