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Volume 16
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10.3390/polym16010144
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Article

Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics

by
Corina-Lenuța Logigan
1,
Christelle Delaite
2,
Marcel Popa
1,3,4,
Elena Simona Băcăiță
5,
Crina Elena Tiron
6,
Cristian Peptu
7 and
Cătălina Anișoara Peptu
1,*
1
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, “Gheorghe Asachi” Technical University of Iasi, Bld. Prof. Dr. Doc. Dimitrie Mangeron Street, No. 73, 700050 Iasi, Romania
2
Laboratory of Photochemistry and Macromolecular Engineering, Institute J.B. Donnet, University of Haute Alsace, 68100 Mulhouse, France
3
Faculty of Medical Dentistry, “Apollonia” University of Iasi, Pacurari Street, 11, Iasi 6600, Romania Muzicii Street, No. 2, 700511 Iasi, Romania
4
Academy of Romanian Scientists, Ilfov Street, No. 3, Sector 5, 050094 Bucharest, Romania
5
Department of Physics, Faculty of Machine Manufacturing and Industrial Management, “Gheorghe Asachi” Technical University of Iasi, Bld. Prof. Dr. Doc. Dimitrie Mangeron Street, No. 73, 700050 Iasi, Romania
6
Regional Institute of Oncology, General Henri Mathias Berthelot Street, 2–4, 700483 Iasi, Romania
7
“Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, 41A, 700487 Iasi, Romania
*
Author to whom correspondence should be addressed.
Polymers 2024, 16(1), 144; https://doi.org/10.3390/polym16010144
Submission received: 10 November 2023 / Revised: 19 December 2023 / Accepted: 29 December 2023 / Published: 2 January 2024
(This article belongs to the Section Polymer Networks and Gels)
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Abstract

Nanotechnology is the science of creating materials at the nanoscale by using various devices, structures, and systems that are often inspired by nature. Micro- and nanoparticles (MPs, NPs) are examples of such materials that have unique properties and can be used as carriers for delivering drugs for different biomedical applications. Chitosan (CS) is a natural polysaccharide that has been widely studied, but it has a problem with low water solubility at neutral or basic pH, which limits its processability. The goal of this work was to use a chemically modified CS with poly(ethylene glycol) methyl ether acrylate (PEGA) to prepare CS micronic and submicronic particles (MPs/NPs) that can deliver different types of antibiotics, respectively, levofloxacin (LEV) and Ciprofloxacin (CIP). The particle preparation procedure employed a double crosslinking method, ionic followed by a covalent, in a water/oil emulsion. The studied process parameters were the precursor concentration, stirring speeds, and amount of ionic crosslinking agent. MPs/NPs were characterized by FT-IR, SEM, light scattering granulometry, and Zeta potential. MPs/NPs were also tested for their water uptake capacity in acidic and neutral pH conditions, and the results showed that they had a pH-dependent behavior. The MPs/NPs were then used to encapsulate two separate drugs, LEV and CIP, and they showed excellent drug loading and release capacity. The MPs/NPs were also found to be safe for cells and blood, which demonstrated their potential as suitable drug delivery systems for biomedical applications.
Keywords: micro/nanoparticles; poly(ethylene glycol) methyl ether acrylate; chitosan; reverse emulsion; interpenetrating network; levofloxacin; ciprofloxacin; biomedical applications micro/nanoparticles; poly(ethylene glycol) methyl ether acrylate; chitosan; reverse emulsion; interpenetrating network; levofloxacin; ciprofloxacin; biomedical applications
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MDPI and ACS Style

Logigan, C.-L.; Delaite, C.; Popa, M.; Băcăiță, E.S.; Tiron, C.E.; Peptu, C.; Peptu, C.A. Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics. Polymers 2024, 16, 144. https://doi.org/10.3390/polym16010144

AMA Style

Logigan C-L, Delaite C, Popa M, Băcăiță ES, Tiron CE, Peptu C, Peptu CA. Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics. Polymers. 2024; 16(1):144. https://doi.org/10.3390/polym16010144

Chicago/Turabian Style

Logigan, Corina-Lenuța, Christelle Delaite, Marcel Popa, Elena Simona Băcăiță, Crina Elena Tiron, Cristian Peptu, and Cătălina Anișoara Peptu. 2024. "Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics" Polymers 16, no. 1: 144. https://doi.org/10.3390/polym16010144

APA Style

Logigan, C.-L., Delaite, C., Popa, M., Băcăiță, E. S., Tiron, C. E., Peptu, C., & Peptu, C. A. (2024). Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics. Polymers, 16(1), 144. https://doi.org/10.3390/polym16010144

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