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Polymers
Volume 15
Issue 3
10.3390/polym15030651
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Article

Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering

by
Mariia Leonovich
1,
Viktor Korzhikov-Vlakh
1,*,
Antonina Lavrentieva
2,
Iliyana Pepelanova
2,
Evgenia Korzhikova-Vlakh
1,3 and
Tatiana Tennikova
1,*
1
Institute of Chemistry, Saint Petersburg State University, Peterhoff, Universitetskii pr. 26, 198504 Saint Petersburg, Russia
2
Institute of Technical Chemistry, Gottfried-Wilhelm-Leibniz University of Hannover, 30167 Hannover, Germany
3
Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, Russia
*
Authors to whom correspondence should be addressed.
Polymers 2023, 15(3), 651; https://doi.org/10.3390/polym15030651
Submission received: 9 December 2022 / Revised: 20 January 2023 / Accepted: 24 January 2023 / Published: 27 January 2023
(This article belongs to the Special Issue Biodegradable Polymers to Biomedical and Packaging Applications)
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Abstract

Different parts of bones possess different properties, such as the capacity for remodeling cell content, porosity, and protein composition. For various traumatic or surgical tissue defects, the application of tissue-engineered constructs seems to be a promising strategy. Despite significant research efforts, such constructs are still rarely available in the clinic. One of the reasons is the lack of resorbable materials, whose properties can be adjusted according to the intended tissue or tissue contacts. Here, we present our first results on the development of a toolbox, by which the scaffolds with easily tunable mechanical and biological properties could be prepared. Biodegradable poly(lactic acid) and nanocrystalline cellulose methacrylated particles were obtained, characterized, and used for preparation of three-dimensional scaffolds via cryogelation and 3D printing approaches. The composition of particles-based ink for 3D printing was optimized in order to allow formation of stable materials. Both the modified-particle cytotoxicity and the matrix-supported cell adhesion were evaluated and visualized in order to confirm the perspectives of materials application.
Keywords: poly(lactic acid); nanocrystalline cellulose; methacrylation; particles; 3D printing; scaffolds; tissue engineering poly(lactic acid); nanocrystalline cellulose; methacrylation; particles; 3D printing; scaffolds; tissue engineering
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MDPI and ACS Style

Leonovich, M.; Korzhikov-Vlakh, V.; Lavrentieva, A.; Pepelanova, I.; Korzhikova-Vlakh, E.; Tennikova, T. Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering. Polymers 2023, 15, 651. https://doi.org/10.3390/polym15030651

AMA Style

Leonovich M, Korzhikov-Vlakh V, Lavrentieva A, Pepelanova I, Korzhikova-Vlakh E, Tennikova T. Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering. Polymers. 2023; 15(3):651. https://doi.org/10.3390/polym15030651

Chicago/Turabian Style

Leonovich, Mariia, Viktor Korzhikov-Vlakh, Antonina Lavrentieva, Iliyana Pepelanova, Evgenia Korzhikova-Vlakh, and Tatiana Tennikova. 2023. "Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering" Polymers 15, no. 3: 651. https://doi.org/10.3390/polym15030651

APA Style

Leonovich, M., Korzhikov-Vlakh, V., Lavrentieva, A., Pepelanova, I., Korzhikova-Vlakh, E., & Tennikova, T. (2023). Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering. Polymers, 15(3), 651. https://doi.org/10.3390/polym15030651

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