Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Volunteers
2.3. Preparation of DMNs
2.4. Characterizations of DMNs
2.5. The PTIO Antioxidant Activity of DMNs
2.6. DPPH• Scavenging Efficiency of DMNs
2.7. Safety on B16-F10 Cells
2.8. Effects of Cellular Tyrosinase Activity
2.9. Melanin Measurement
2.10. Zebrafish Experiment
2.11. Clinical Research in DMNs
2.12. Statistical Analysis
3. Results and Discussion
3.1. Preparation and Characterization of DMNs
3.2. Antioxidant Results of DMNs
3.3. Cytotoxicity Results of DMNs
3.4. Effect of DMNs on The Activity of Tyrosinase in B16-F10 Cells
3.5. Effect of DMNs on Melanin Production in B16-F10 Cells
3.6. Effect of DMNs on Melanin Pigmentation of Zebrafish Embryos
3.7. The Clinical Trial of DMNs
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Yan, C.; Xing, M.; Zhang, S.; Gao, Y. Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders. Polymers 2023, 15, 3296. https://doi.org/10.3390/polym15153296
Yan C, Xing M, Zhang S, Gao Y. Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders. Polymers. 2023; 15(15):3296. https://doi.org/10.3390/polym15153296
Chicago/Turabian StyleYan, Chenxin, Mengzhen Xing, Suohui Zhang, and Yunhua Gao. 2023. "Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders" Polymers 15, no. 15: 3296. https://doi.org/10.3390/polym15153296