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Polymers
Volume 14
Issue 19
10.3390/polym14194141
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Review

Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals

by
Murtada Taha
1,
Nabil A. Alhakamy
2,
Shadab Md
2,
Mohammad Zaki Ahmad
3,
Md. Rizwanullah
4,
Sana Fatima
5,
Naveed Ahmed
6,
Faisal M. Alyazedi
6,
Shahid Karim
7 and
Javed Ahmad
3,*
1
Department of Clinical Laboratory Science, Prince Sultan Military College of Health Sciences, Dhahran 31932, Saudi Arabia
2
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
3
Department of Pharmaceutics, College of Pharmacy, Najran University, Najran 11001, Saudi Arabia
4
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, Delhi, India
5
Sufia Unani Medical College Hospital & Research Centre, Bara Chakia, Motihari 845412, Bihar, India
6
Prince Sultan Military College of Health Sciences, Dhahran 31932, Saudi Arabia
7
Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Polymers 2022, 14(19), 4141; https://doi.org/10.3390/polym14194141
Submission received: 8 September 2022 / Revised: 21 September 2022 / Accepted: 22 September 2022 / Published: 3 October 2022
(This article belongs to the Special Issue Research Progress of Polymer Nanomaterials for Drug Delivery)
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Abstract

Nanogel is a promising drug delivery approach to improve the pharmacokinetics and pharmacodynamic prospect of phytopharmaceuticals. In the present review, phytopharmaceuticals with astonishing therapeutic utilities are being explored. However, their in vivo delivery is challenging, owing to poor biopharmaceutical attributes that impact their drug release profile, skin penetration, and the reach of optimal therapeutic concentrations to the target site. Nanogel and its advanced version in the form of nanoemulgel (oil-in-water nanoemulsion integrated gel matrix) offer better therapeutic prospects than other conventional counterparts for improving the biopharmaceutical attributes and thus therapeutic efficacy of phytopharmaceuticals. Nanoemulgel-loaded phytopharmaceuticals could substantially improve permeation behavior across skin barriers, subsequently enhancing the delivery and therapeutic effectiveness of the bioactive compound. Furthermore, the thixotropic characteristics of polymeric hydrogel utilized in the fabrication of nanogel/nanoemulgel-based drug delivery systems have also imparted improvements in the biopharmaceutical attributes of loaded phytopharmaceuticals. This formulation approach is about to be rife in the coming decades. Thus, the current review throws light on the recent studies demonstrating the role of nanogels in enhancing the delivery of bioactive compounds for treating various disease conditions and the challenges faced in their clinical translation.
Keywords: nanogels; phytopharmaceuticals; biopharmaceutical attributes; nanoemulgel; thixotropy; skin permeation; therapeutic efficacy nanogels; phytopharmaceuticals; biopharmaceutical attributes; nanoemulgel; thixotropy; skin permeation; therapeutic efficacy

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MDPI and ACS Style

Taha, M.; Alhakamy, N.A.; Md, S.; Ahmad, M.Z.; Rizwanullah, M.; Fatima, S.; Ahmed, N.; Alyazedi, F.M.; Karim, S.; Ahmad, J. Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals. Polymers 2022, 14, 4141. https://doi.org/10.3390/polym14194141

AMA Style

Taha M, Alhakamy NA, Md S, Ahmad MZ, Rizwanullah M, Fatima S, Ahmed N, Alyazedi FM, Karim S, Ahmad J. Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals. Polymers. 2022; 14(19):4141. https://doi.org/10.3390/polym14194141

Chicago/Turabian Style

Taha, Murtada, Nabil A. Alhakamy, Shadab Md, Mohammad Zaki Ahmad, Md. Rizwanullah, Sana Fatima, Naveed Ahmed, Faisal M. Alyazedi, Shahid Karim, and Javed Ahmad. 2022. "Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals" Polymers 14, no. 19: 4141. https://doi.org/10.3390/polym14194141

APA Style

Taha, M., Alhakamy, N. A., Md, S., Ahmad, M. Z., Rizwanullah, M., Fatima, S., Ahmed, N., Alyazedi, F. M., Karim, S., & Ahmad, J. (2022). Nanogels as Potential Delivery Vehicles in Improving the Therapeutic Efficacy of Phytopharmaceuticals. Polymers, 14(19), 4141. https://doi.org/10.3390/polym14194141

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