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Open AccessArticle

Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation

1
Chair for Multicomponent Materials, Institute for Materials Science, Faculty of Engineering, Kiel University, Kaiserstr. 2, 24143 Kiel, Germany
2
Department of Periodontology, University Hospital of Bonn, D-53111 Bonn, Germany
3
Department of Oral and Maxillofacial Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105 Kiel, Germany
4
Marine Science and Technology Faculty, Iskenderun Technical University, 31200 Iskenderun, Turkey
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Mads Clausen Institute, NanoSYD, University of Southern Denmark, Alsion 2, 6400 Sønderborg, Denmark
6
Department of Periodontology, Cankiri Karatekin University, 18100 Cankiri, Turkey
7
Department of Medical Biochemistry, SANKO University, Şehitkamil, 27090 Gaziantep, Turkey
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Alejandro Sosnik
Polymers 2021, 13(6), 847; https://doi.org/10.3390/polym13060847
Received: 13 February 2021 / Revised: 5 March 2021 / Accepted: 8 March 2021 / Published: 10 March 2021
(This article belongs to the Section Polymer Applications)
Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs’ adhesion and proliferation. View Full-Text
Keywords: composite patch; marine algae; osteoblast; sarcoma; sargassum vulgare composite patch; marine algae; osteoblast; sarcoma; sargassum vulgare
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MDPI and ACS Style

Veziroglu, S.; Ayna, M.; Kohlhaas, T.; Sayin, S.; Fiutowski, J.; Mishra, Y.K.; Karayürek, F.; Naujokat, H.; Saygili, E.I.; Açil, Y.; Wiltfang, J.; Faupel, F.; Aktas, O.C.; Gülses, A. Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation. Polymers 2021, 13, 847. https://doi.org/10.3390/polym13060847

AMA Style

Veziroglu S, Ayna M, Kohlhaas T, Sayin S, Fiutowski J, Mishra YK, Karayürek F, Naujokat H, Saygili EI, Açil Y, Wiltfang J, Faupel F, Aktas OC, Gülses A. Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation. Polymers. 2021; 13(6):847. https://doi.org/10.3390/polym13060847

Chicago/Turabian Style

Veziroglu, Salih; Ayna, Mustafa; Kohlhaas, Theresa; Sayin, Selin; Fiutowski, Jacek; Mishra, Yogendra K.; Karayürek, Fatih; Naujokat, Hendrik; Saygili, Eyüp I.; Açil, Yahya; Wiltfang, Jörg; Faupel, Franz; Aktas, Oral C.; Gülses, Aydin. 2021. "Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation" Polymers 13, no. 6: 847. https://doi.org/10.3390/polym13060847

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