Next Article in Journal
Application of Nanotechnology to Improve the Performance of Biodegradable Biopolymer-Based Packaging Materials
Next Article in Special Issue
Development and Evaluation of Nanoparticles-in-Film Technology to Achieve Extended In Vivo Exposure of MK-2048 for HIV Prevention
Previous Article in Journal
Esterification of Cellulose with Long Fatty Acid Chain through Mechanochemical Method
Previous Article in Special Issue
Self-Assembly of Soluble Chitosan Derivatives Nanoparticles for Vaccine: Synthesis, Characterization and Evaluation
Review

Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations

1
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India
2
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
3
Center of Excellence for Drug Research & Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editors: Ankit K. Rochani, John Eisenbrey and Gagan Kaushal
Polymers 2021, 13(24), 4400; https://doi.org/10.3390/polym13244400
Received: 22 November 2021 / Revised: 10 December 2021 / Accepted: 12 December 2021 / Published: 15 December 2021
This manuscript aims to provide the latest update on polymeric nanoparticle drug delivery system for breast cancer treatment after 2015 and how research-oriented it is based on the available research data. Therefore, the authors have chosen breast cancer which is the most frequent and common reason for mortality in women worldwide. The first-line treatment for breast cancer treatment is chemotherapy, apart from surgery, radiation and hormonal therapy. Chemotherapy is associated with lesser therapeutics and undesirable side effects and hence. In addition, drug resistance affects the therapeutic dose to the target site. Although various nano-based formulations have been developed for effective treatment, the polymeric nanoparticles effectively avoid the lacunae of conventional chemotherapy. There has been an effort made to understand the chemotherapy drugs and their conventional formulation-related problems for better targeting and effective drug delivery for breast cancer treatment. Thus, the polymeric nanoparticles as a strategy overcome the associated problems with resulting dose reduction, enhanced bioavailability, reduced side effects, etc. This present review has compiled the research reports published from 2015 to 2021 from different databases, such as PubMed, Google Scholar, ScienceDirect, which are related to breast cancer treatment in which the drug delivery of numerous chemotherapeutic agents alone or in combination, including phytoconstituents formulated into various polymer-based nanoparticles. View Full-Text
Keywords: breast cancer; chemotherapy; phytoconstituents; polymeric nanoparticles; multi-drug resistance; side effects breast cancer; chemotherapy; phytoconstituents; polymeric nanoparticles; multi-drug resistance; side effects
Show Figures

Figure 1

MDPI and ACS Style

Sartaj, A.; Qamar, Z.; Qizilbash, F.F.; Annu; Md, S.; Alhakamy, N.A.; Baboota, S.; Ali, J. Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations. Polymers 2021, 13, 4400. https://doi.org/10.3390/polym13244400

AMA Style

Sartaj A, Qamar Z, Qizilbash FF, Annu, Md S, Alhakamy NA, Baboota S, Ali J. Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations. Polymers. 2021; 13(24):4400. https://doi.org/10.3390/polym13244400

Chicago/Turabian Style

Sartaj, Ali, Zufika Qamar, Farheen F. Qizilbash, Annu, Shadab Md, Nabil A. Alhakamy, Sanjula Baboota, and Javed Ali. 2021. "Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations" Polymers 13, no. 24: 4400. https://doi.org/10.3390/polym13244400

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop