Next Article in Journal
Polyureas Versatile Polymers for New Academic and Technological Applications
Previous Article in Journal
Chiral Nematic Cellulose Nanocrystal Films Cooperated with Amino Acids for Tunable Optical Properties
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Polymers
Volume 13
Issue 24
10.3390/polym13244390
polymers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis

by
Alda Malagón-Escandón
1,
Mathieu Hautefeuille
2,
Edgar Jimenez-Díaz
2,
Jesus Arenas-Alatorre
3,
José Manuel Saniger
4,
Isidro Badillo-Ramírez
4,
Nadia Vazquez
1,
Gabriela Piñón-Zarate
1 and
Andrés Castell-Rodríguez
1,*
1
Facultad de Medicina, UNAM, Mexico City C.P. 04510, Mexico
2
Facultad de Ciencias, UNAM, Mexico City C.P. 04510, Mexico
3
Instituto de Física, UNAM, Mexico City C.P. 04510, Mexico
4
Instituto de Ciencias Aplicadas y Tecnología (ICAT), UNAM, Mexico City C.P. 04510, Mexico
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(24), 4390; https://doi.org/10.3390/polym13244390
Submission received: 26 October 2021 / Revised: 28 November 2021 / Accepted: 1 December 2021 / Published: 15 December 2021
(This article belongs to the Special Issue Polymers for Tissue Engineering and Regenerative Medicine)
Browse Figures
Review Reports Versions Notes

Abstract

The use of three-dimensional porous scaffolds derived from decellularized extracellular matrix (ECM) is increasing for functional repair and regeneration of injured bone tissue. Because these scaffolds retain their native structures and bioactive molecules, in addition to showing low immunogenicity and good biodegradability, they can promote tissue repair and regeneration. Nonetheless, imitating these features in synthetic materials represents a challenging task. Furthermore, due to the complexity of bone tissue, different processes are necessary to maintain these characteristics. We present a novel approach using decellularized ECM material derived from bovine cancellous bone by demineralization, decellularization, and hydrolysis of collagen to obtain a three-dimensional porous scaffold. This study demonstrates that the three-dimensional porous scaffold obtained from bovine bone retained its osteoconductive and osteoinductive properties and presented osteogenic potential when seeded with human Wharton’s jelly mesenchymal stromal cells (hWJ-MSCs). Based on its characteristics, the scaffold described in this work potentially represents a therapeutic strategy for bone repair.
Keywords: three-dimensional porous scaffolds; bone extracellular matrix; bone regeneration; tissue engineering; biomaterials three-dimensional porous scaffolds; bone extracellular matrix; bone regeneration; tissue engineering; biomaterials

Share and Cite

MDPI and ACS Style

Malagón-Escandón, A.; Hautefeuille, M.; Jimenez-Díaz, E.; Arenas-Alatorre, J.; Saniger, J.M.; Badillo-Ramírez, I.; Vazquez, N.; Piñón-Zarate, G.; Castell-Rodríguez, A. Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis. Polymers 2021, 13, 4390. https://doi.org/10.3390/polym13244390

AMA Style

Malagón-Escandón A, Hautefeuille M, Jimenez-Díaz E, Arenas-Alatorre J, Saniger JM, Badillo-Ramírez I, Vazquez N, Piñón-Zarate G, Castell-Rodríguez A. Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis. Polymers. 2021; 13(24):4390. https://doi.org/10.3390/polym13244390

Chicago/Turabian Style

Malagón-Escandón, Alda, Mathieu Hautefeuille, Edgar Jimenez-Díaz, Jesus Arenas-Alatorre, José Manuel Saniger, Isidro Badillo-Ramírez, Nadia Vazquez, Gabriela Piñón-Zarate, and Andrés Castell-Rodríguez. 2021. "Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis" Polymers 13, no. 24: 4390. https://doi.org/10.3390/polym13244390

APA Style

Malagón-Escandón, A., Hautefeuille, M., Jimenez-Díaz, E., Arenas-Alatorre, J., Saniger, J. M., Badillo-Ramírez, I., Vazquez, N., Piñón-Zarate, G., & Castell-Rodríguez, A. (2021). Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis. Polymers, 13(24), 4390. https://doi.org/10.3390/polym13244390

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop