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Volume 13
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10.3390/polym13111832
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Article

Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers

by
Nikolay Ivanovich Gorshkov
1,*,
Andrei Yur'evich Murko
1,
Yulia Igorevna Zolotova
1,
Olga Vladimirovna Nazarova
1,
Valerii Dmitrievich Krasikov
1,
Sergei Vasilievich Shatik
2 and
Evgenii Fedorovich Panarin
1
1
Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), Russian Federation, V.O. Bolshoy pr. 31, 199004 Saint Petersburg, Russia
2
Federal State Budgetary Institution “Russian Research Center for Radiology and Surgical Technologies” of the Ministry of Health of the Russian Federation, Russian Federation, p. Pesochny, ul. Leningradskaya, 70, 197758 Saint Petersburg, Russia
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(11), 1832; https://doi.org/10.3390/polym13111832
Submission received: 19 March 2021 / Revised: 20 May 2021 / Accepted: 20 May 2021 / Published: 1 June 2021
(This article belongs to the Special Issue Coordination Polymers: Properties and Applications)
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Abstract

N-vinylpyrrolidone-co-allylamine copolymers (VP-co-AA) containing iminodiacetic (IDA) chelation units were prepared in the range of molecular masses of the copolymers from 9000 to 30,000 Da depending on polymerization conditions. Non-radioactive organometallic species Re(CO)3+ were introduced into polymeric carriers under mild conditions; the prepared metal–polymeric complexes were characterized by IR, NMR, ESI-MS and HPLC. IR spectra data confirmed the coordination of M(CO)3+ moiety to the polymeric backbone via IDA chelation unit (appearance of characteristic fac-M(CO)3+ vibrations (2005, 1890 cm−1), as well as the appearance of group of signals in 1H NMR spectra, corresponding to those inequivalent to methylene protons CH2COO (dd, 4.2 ppm), coordinated to metal ions. The optimal conditions for labeling the PVP-co-AA-IDA copolymers with radioactive 99mTc(CO)3+ species were determined. The radiochemical yields reached 97%. The obtained radiolabeled polymers were stable in blood serum for 3 h. In vivo distribution experiments in intact animals showed the high primary accumulation of technetium-99m MPC (MM = 15,000 Da) in blood with subsequent excretion via the urinary tract.
Keywords: vinylpyrrolidone-allylamine copolymers; iminodiacetate chelator; carbonyl; rhenium; technetium-99m vinylpyrrolidone-allylamine copolymers; iminodiacetate chelator; carbonyl; rhenium; technetium-99m

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MDPI and ACS Style

Gorshkov, N.I.; Murko, A.Y.; Zolotova, Y.I.; Nazarova, O.V.; Krasikov, V.D.; Shatik, S.V.; Panarin, E.F. Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers. Polymers 2021, 13, 1832. https://doi.org/10.3390/polym13111832

AMA Style

Gorshkov NI, Murko AY, Zolotova YI, Nazarova OV, Krasikov VD, Shatik SV, Panarin EF. Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers. Polymers. 2021; 13(11):1832. https://doi.org/10.3390/polym13111832

Chicago/Turabian Style

Gorshkov, Nikolay Ivanovich, Andrei Yur'evich Murko, Yulia Igorevna Zolotova, Olga Vladimirovna Nazarova, Valerii Dmitrievich Krasikov, Sergei Vasilievich Shatik, and Evgenii Fedorovich Panarin. 2021. "Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers" Polymers 13, no. 11: 1832. https://doi.org/10.3390/polym13111832

APA Style

Gorshkov, N. I., Murko, A. Y., Zolotova, Y. I., Nazarova, O. V., Krasikov, V. D., Shatik, S. V., & Panarin, E. F. (2021). Introduction of Re(CO)3+/99mTc(CO)3+ Organometallic Species into Vinylpyrrolidone-Allyliminodiacetate Copolymers. Polymers, 13(11), 1832. https://doi.org/10.3390/polym13111832

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