Next Article in Journal
Synthesis and Properties of Thermotropic Copolyesters Based on Poly(ethylene terephthalate) and 4′-Acetoxy-4-biphenyl-carboxylic Acid
Previous Article in Journal
Novel Multifunctional Epoxy (Meth)Acrylate Resins and Coatings Preparation via Cationic and Free-Radical Photopolymerization
 
 
Article

Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films

1
Advanced Materials Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia
2
Jožef Stefan International Postgraduate School, 1000 Ljubljana, Slovenia
3
Condensed Matter Physics Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia
4
Institute of Physics Belgrade, University of Belgrade, Pregrevica 118, 11080 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Academic Editor: Roman A. Surmenev
Polymers 2021, 13(11), 1719; https://doi.org/10.3390/polym13111719
Received: 29 April 2021 / Revised: 18 May 2021 / Accepted: 21 May 2021 / Published: 24 May 2021
(This article belongs to the Special Issue Stimuli-Responsive Biomaterials: Piezoelectric Biomaterials)
Biocompatible and biodegradable poly-l-lactic acid (PLLA) processed into piezoelectric structures has good potential for use in medical applications, particularly for promoting cellular growth during electrostimulation. Significant advantages like closer contacts between cells and films are predicted when their surfaces are modified to make them more hydrophilic. However, there is an open question about whether the surface modification will affect the degradation process and how the films will be changed as a result. For the first time, we demonstrate that improving the polymer surface’s wettability affects the position of enzyme-driven degradation. Although it is generally considered that proteinase K degrades only the polymer surface, we observed the enzyme’s ability to induce both surface and bulk degradation. In hydrophilic films, degradation occurs at the surface, inducing surface erosion, while for hydrophobic films, it is located inside the films, inducing bulk erosion. Accordingly, changes in the structural, morphological, mechanical, thermal and wetting properties of the film resulting from degradation vary, depending on the film’s wettability. Most importantly, the degradation is gradual, so the mechanical and piezoelectric properties are retained during the degradation. View Full-Text
Keywords: poly-l-lactic acid; enzymatically catalyzed degradation; piezoelectricity; bulk erosion; surface erosion poly-l-lactic acid; enzymatically catalyzed degradation; piezoelectricity; bulk erosion; surface erosion
Show Figures

Graphical abstract

MDPI and ACS Style

Gazvoda, L.; Višić, B.; Spreitzer, M.; Vukomanović, M. Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films. Polymers 2021, 13, 1719. https://doi.org/10.3390/polym13111719

AMA Style

Gazvoda L, Višić B, Spreitzer M, Vukomanović M. Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films. Polymers. 2021; 13(11):1719. https://doi.org/10.3390/polym13111719

Chicago/Turabian Style

Gazvoda, Lea, Bojana Višić, Matjaž Spreitzer, and Marija Vukomanović. 2021. "Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films" Polymers 13, no. 11: 1719. https://doi.org/10.3390/polym13111719

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop