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Article

Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties

1
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, Russia
2
Institute for Regenerative Medicine, Sechenov University, 8-2 Trubetskaya st., 119991 Moscow, Russia
3
Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina st., 119991 Moscow, Russia
4
Faculty of Biology, Lomonosov Moscow State University, 12-1, Leninskie Gory, 119234 Moscow, Russia
5
FSBSI “Institute of General Pathology and Pathophysiology”, 8, Baltiyskaya st., 125315 Moscow, Russia
6
Chemistry Department, Lomonosov Moscow State University, 1-3 Leninskiye Gory, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(9), 1911; https://doi.org/10.3390/polym12091911
Received: 30 June 2020 / Revised: 15 August 2020 / Accepted: 19 August 2020 / Published: 25 August 2020
(This article belongs to the Special Issue Polymer-Based Nanocomposites for Biomedical Applications)
The mimicking of the architectonics of native tissue, biodegradable non-woven fibrous mats is one of the most promising forms of scaffolding for tissue engineering. The key properties needed for their successful application in vivo, such as biodegradability, biocompatibility, morphology, mechanical properties, etc., rely on their composition and appropriate 3D structure. A multicomponent system based on biodegradable synthetic (polycaprolactone, oligo-/polylactide) and natural (chitosan, gelatin) polymers, providing the desired processing characteristics and functionality to non-woven mats fabricated via the electrospinning technique, was developed. The solid-state reactive blending of these components provided a one-step synthesis of amphiphilic graft copolymer with an ability to form stable ultra-fine dispersions in chlorinated solvents, which could be successfully used as casting solvents for the electrospinning technique. The synthesized graft copolymer was analyzed with the aim of fractional analysis, dynamic laser scattering, FTIR-spectroscopy and DSC. Casting solution characteristics, namely viscosity, surface tension, and electroconductivity, as well as electrospinning parameters, were studied and optimized. The morphology, chemical structure of the surface layer, mechanical properties and cytocompatibility were analyzed to confirm the appropriate functionality of the formed fibrous materials as scaffolds for tissue engineering. View Full-Text
Keywords: polyesters; gelatin; chitosan; solvent-free co-extrusion; non-woven mats; electrospinning; cytocompatibility polyesters; gelatin; chitosan; solvent-free co-extrusion; non-woven mats; electrospinning; cytocompatibility
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MDPI and ACS Style

Demina, T.S.; Kuryanova, A.S.; Bikmulina, P.Y.; Aksenova, N.A.; Efremov, Y.M.; Khaibullin, Z.I.; Ivanov, P.L.; Kosheleva, N.V.; Timashev, P.S.; Akopova, T.A. Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties. Polymers 2020, 12, 1911. https://doi.org/10.3390/polym12091911

AMA Style

Demina TS, Kuryanova AS, Bikmulina PY, Aksenova NA, Efremov YM, Khaibullin ZI, Ivanov PL, Kosheleva NV, Timashev PS, Akopova TA. Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties. Polymers. 2020; 12(9):1911. https://doi.org/10.3390/polym12091911

Chicago/Turabian Style

Demina, Tatiana S., Anastasia S. Kuryanova, Polina Y. Bikmulina, Nadejda A. Aksenova, Yuri M. Efremov, Zulfar I. Khaibullin, Pavel L. Ivanov, Nastasia V. Kosheleva, Peter S. Timashev, and Tatiana A. Akopova 2020. "Multicomponent Non-Woven Fibrous Mats with Balanced Processing and Functional Properties" Polymers 12, no. 9: 1911. https://doi.org/10.3390/polym12091911

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