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Article

A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks

1
Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion—Israel Institute of Technology, Haifa 3200003, Israel
2
Mechanics of Soft Materials, Department of Materials Science and Engineering, Technion—Israel Institute of Technology, Haifa 3200003, Israel
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(9), 1912; https://doi.org/10.3390/polym12091912
Received: 6 August 2020 / Revised: 22 August 2020 / Accepted: 24 August 2020 / Published: 25 August 2020
(This article belongs to the Special Issue Theory of Polymers at Interfaces)
Biological gels (bio-gels) are hydrated polymer networks that serve diverse biological functions, which often lead to intentional or unintentional exposure to particulate matter. In this work, we derive a microscopically motivated framework that enables the investigation of penetration mechanisms into bio-gels. We distinguish between two types of mechanisms: spontaneous (unforced) penetration and forced penetration. Using experimental data available in the literature, we exploit the proposed model to characterize and compare between the microstructures of respiratory, intestinal, and cervicovaginal mucus and two types of biofilms. Next, we investigate the forced penetration process of spherical and ellipsoidal particles into a locally quadrilateral network. The proposed framework can be used to improve and complement the analysis of experimental findings in vitro, ex vivo, and in vivo. Additionally, the insights from this work pave the way towards enhanced designs of nano-medicines and allow the assessment of risk factors related to the nano-pollutants exposure. View Full-Text
Keywords: penetration mechanisms; gels; particles; mucus; biofilms; multi-scale modeling penetration mechanisms; gels; particles; mucus; biofilms; multi-scale modeling
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MDPI and ACS Style

Arzi, R.S.; Sosnik, A.; Cohen, N. A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks. Polymers 2020, 12, 1912. https://doi.org/10.3390/polym12091912

AMA Style

Arzi RS, Sosnik A, Cohen N. A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks. Polymers. 2020; 12(9):1912. https://doi.org/10.3390/polym12091912

Chicago/Turabian Style

Arzi, Roni S., Alejandro Sosnik, and Noy Cohen. 2020. "A Microscopically Motivated Model for Particle Penetration into Swollen Biological Networks" Polymers 12, no. 9: 1912. https://doi.org/10.3390/polym12091912

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