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Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology

Secció de Bioquímica i Biologia Molecular, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Joan XXIII 27–31, 08028 Barcelona, Spain
Departament d’Enginyeria Química, Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Spain
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Polymers 2020, 12(5), 1177;
Received: 29 April 2020 / Revised: 19 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
(This article belongs to the Special Issue Functional Chitosan-Based Composites)
Chitosan is increasingly used for safe nucleic acid delivery in gene therapy studies, due to well-known properties such as bioadhesion, low toxicity, biodegradability and biocompatibility. Furthermore, chitosan derivatization can be easily performed to improve the solubility and stability of chitosan–nucleic acid polyplexes, and enhance efficient target cell drug delivery, cell uptake, intracellular endosomal escape, unpacking and nuclear import of expression plasmids. As in other fields, chitosan is a promising drug delivery vector with great potential for the fish farming industry. This review highlights state-of-the-art assays using chitosan-based methodologies for delivering nucleic acids into cells, and focuses attention on recent advances in chitosan-mediated gene delivery for fish biotechnology applications. The efficiency of chitosan for gene therapy studies in fish biotechnology is discussed in fields such as fish vaccination against bacterial and viral infection, control of gonadal development and gene overexpression and silencing for overcoming metabolic limitations, such as dependence on protein-rich diets and the low glucose tolerance of farmed fish. Finally, challenges and perspectives on the future developments of chitosan-based gene delivery in fish are also discussed. View Full-Text
Keywords: chitosan; gene delivery; gene overexpression; gene silencing; fish biotechnology chitosan; gene delivery; gene overexpression; gene silencing; fish biotechnology
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MDPI and ACS Style

Wu, Y.; Rashidpour, A.; Almajano, M.P.; Metón, I. Chitosan-Based Drug Delivery System: Applications in Fish Biotechnology. Polymers 2020, 12, 1177.

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