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Open AccessFeature PaperArticle

Development and Performance of Bioactive Compounds-Loaded Cellulose/Collagen/Polyurethane Materials

1
“Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica–Vodă 41, 700487 Iași, Romania
2
Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy, 9-13 Kogălniceanu Street, 700454 Iași, Romania
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(5), 1191; https://doi.org/10.3390/polym12051191
Received: 30 April 2020 / Revised: 19 May 2020 / Accepted: 20 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue Functional Chitosan-Based Composites)
Here we present a new biomaterial based on cellulose, collagen and polyurethane, obtained by dissolving in butyl imidazole chloride. This material served as a matrix for the incorporation of tannin and lipoic acid, as well as bioactive substances with antioxidant properties. The introduction of these bioactive principles into the base matrix led to an increase of the compressive strength in the range 105–139 kPa. An increase of 29.85% of the mucoadhesiveness of the film containing tannin, as compared to the reference, prolongs the bioavailability of the active substance; a fact also demonstrated by the controlled release studies. The presence of bioactive principles, as well as tannins and lipoic acid, gives biomaterials an antioxidant capacity on average 40%–50% higher compared to the base matrix. The results of the tests of the mechanical resistance, mucoadhesiveness, bioadhesiveness, water absorption and antioxidant capacity of active principles recommend these biomaterials for the manufacture of cosmetic masks or patches. View Full-Text
Keywords: cellulose; collagen; biomaterials; tannins; lipoic acid; Quercus robur L. cellulose; collagen; biomaterials; tannins; lipoic acid; Quercus robur L.
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MDPI and ACS Style

Spiridon, I.; Anghel, N.; Dinu, M.V.; Vlad, S.; Bele, A.; Ciubotaru, B.I.; Verestiuc, L.; Pamfil, D. Development and Performance of Bioactive Compounds-Loaded Cellulose/Collagen/Polyurethane Materials. Polymers 2020, 12, 1191.

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