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Open AccessArticle

Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition

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Department of Polymers Technology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80233 Gdansk, Poland
2
Department of Solid State Physics, Faculty of Applied Physics and Mathematics, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80233 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(2), 410; https://doi.org/10.3390/polym12020410
Received: 19 November 2019 / Revised: 1 February 2020 / Accepted: 4 February 2020 / Published: 11 February 2020
(This article belongs to the Section Biobased and Biodegradable Polymers)
The skeleton is a crucial element of the motion system in the human body, whose main function is to support and protect the soft tissues. Furthermore, the elements of the skeleton act as a storage place for minerals and participate in the production of red blood cells. The bone tissue includes the craniomaxillofacial bones, ribs, and spine. There are abundant reports in the literature indicating that the amount of treatments related to bone fractures increases year by year. Nowadays, the regeneration of the bone tissue is performed by using autografts or allografts, but this treatment method possesses a few disadvantages. Therefore, new and promising methods of bone tissue regeneration are constantly being sought. They often include the implantation of tissue scaffolds, which exhibit proper mechanical and osteoconductive properties. In this paper, the preparation of polyurethane (PUR) scaffolds modified by gelatin as the reinforcing factor and hydroxyapatite as the bioactive agent was described. The unmodified and modified scaffolds were tested for their mechanical properties; morphological assessments using optical microscopy were also conducted, as was the ability for calcification using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Moreover, each type of scaffold was subjected to a degradation process in 5M NaOH and 2M HCl aqueous solutions. It was noticed that the best properties promoting the calcium phosphate deposition were obtained for scaffolds modified with 2% gelatin solution containing 5% of hydroxyapatite.
Keywords: hydroxyapatite; gelatin; bone tissue; polyurethane scaffold hydroxyapatite; gelatin; bone tissue; polyurethane scaffold
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MDPI and ACS Style

Iga, C.; Paweł, S.; Marcin, Ł.; Justyna, K.-L. Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition. Polymers 2020, 12, 410.

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