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Open AccessArticle

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

1
Department of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, China
2
College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China
3
Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan
4
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(2), 380; https://doi.org/10.3390/polym12020380
Received: 24 December 2019 / Revised: 30 January 2020 / Accepted: 2 February 2020 / Published: 8 February 2020
(This article belongs to the Special Issue Synthesis and Applications of Functional Polymer Nanocarriers)
In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX. View Full-Text
Keywords: chitosan; cholesterol; micelles; mPEG; redox-responsive chitosan; cholesterol; micelles; mPEG; redox-responsive
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MDPI and ACS Style

Han, Y.; Liang, N.; Yan, P.; Kawashima, Y.; Cui, F.; Sun, S. A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel. Polymers 2020, 12, 380.

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