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An Overview of Additive Manufacturing of Polymers and Associated Composites

Photo-Crosslinked Silk Fibroin for 3D Printing

Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA
Department of Physics and Astronomy, Tufts University, Medford, MA 02155, USA
Author to whom correspondence should be addressed.
Present address: Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Polymers 2020, 12(12), 2936;
Received: 19 November 2020 / Revised: 4 December 2020 / Accepted: 7 December 2020 / Published: 9 December 2020
Silk fibroin in material formats provides robust mechanical properties, and thus is a promising protein for 3D printing inks for a range of applications, including tissue engineering, bioelectronics, and bio-optics. Among the various crosslinking mechanisms, photo-crosslinking is particularly useful for 3D printing with silk fibroin inks due to the rapid kinetics, tunable crosslinking dynamics, light-assisted shape control, and the option to use visible light as a biocompatible processing condition. Multiple photo-crosslinking approaches have been applied to native or chemically modified silk fibroin, including photo-oxidation and free radical methacrylate polymerization. The molecular characteristics of silk fibroin, i.e., conformational polymorphism, provide a unique method for crosslinking and microfabrication via light. The molecular design features of silk fibroin inks and the exploitation of photo-crosslinking mechanisms suggest the exciting potential for meeting many biomedical needs in the future. View Full-Text
Keywords: proteins; silk; additive manufacturing; photo-initiators; tyrosine; free radicals proteins; silk; additive manufacturing; photo-initiators; tyrosine; free radicals
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MDPI and ACS Style

Mu, X.; Sahoo, J.K.; Cebe, P.; Kaplan, D.L. Photo-Crosslinked Silk Fibroin for 3D Printing. Polymers 2020, 12, 2936.

AMA Style

Mu X, Sahoo JK, Cebe P, Kaplan DL. Photo-Crosslinked Silk Fibroin for 3D Printing. Polymers. 2020; 12(12):2936.

Chicago/Turabian Style

Mu, Xuan, Jugal K. Sahoo, Peggy Cebe, and David L. Kaplan 2020. "Photo-Crosslinked Silk Fibroin for 3D Printing" Polymers 12, no. 12: 2936.

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