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Open AccessArticle

FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends

1
Institute of Material Chemistry, Faculty of Chemistry, Brno University of Technology, Purkyňova 464/118, 612 00 Brno, Czech Republic
2
Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague 4, Czech Republic
3
CEITEC—Central European Institute of Technology, Brno University of Technology, Advanced Biomaterials, Purkyňova 656/123, 612 00 Brno, Czech Republic
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(12), 2806; https://doi.org/10.3390/polym12122806
Received: 31 October 2020 / Revised: 21 November 2020 / Accepted: 23 November 2020 / Published: 27 November 2020
(This article belongs to the Special Issue Sustainable Polymers from Biomass)
Tissue engineering is a current trend in the regenerative medicine putting pressure on scientists to develop highly functional materials and methods for scaffolds’ preparation. In this paper, the calibrated filaments for Fused Deposition Modeling (FDM) based on plasticized poly(3-hydroxybutyrate)/poly(d,l-lactide) 70/30 blend modified with tricalcium phosphate bioceramics were prepared. Two different plasticizers, Citroflex (n-Butyryl tri-n-hexyl citrate) and Syncroflex (oligomeric adipate ester), both used in the amount of 12 wt%, were compared. The printing parameters for these materials were optimized and the printability was evaluated by recently published warping test. The samples were studied with respect to their thermal and mechanical properties, followed by biological in vitro tests including proliferation, viability, and osteogenic differentiation of human mesenchymal stem cells. According to the results from differential scanning calorimetry and tensile measurements, the Citroflex-based plasticizer showed very good softening effect at the expense of worse printability and unsatisfactory performance during biological testing. On the other hand, the samples with Syncroflex demonstrated lower warping tendency compared to commercial polylactide filament with the warping coefficient one third lower. Moreover, the Syncroflex-based samples exhibited the non-cytotoxicity and promising biocompatibility. View Full-Text
Keywords: additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds additive manufacturing; fused deposition modeling; poly(3-hydroxybutyrate); polylactide; tricalcium phosphate; regenerative medicine; tissue engineering; bone scaffolds
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MDPI and ACS Style

Melčová, V.; Svoradová, K.; Menčík, P.; Kontárová, S.; Rampichová, M.; Hedvičáková, V.; Sovková, V.; Přikryl, R.; Vojtová, L. FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends. Polymers 2020, 12, 2806. https://doi.org/10.3390/polym12122806

AMA Style

Melčová V, Svoradová K, Menčík P, Kontárová S, Rampichová M, Hedvičáková V, Sovková V, Přikryl R, Vojtová L. FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends. Polymers. 2020; 12(12):2806. https://doi.org/10.3390/polym12122806

Chicago/Turabian Style

Melčová, Veronika; Svoradová, Kateřina; Menčík, Přemysl; Kontárová, Soňa; Rampichová, Michala; Hedvičáková, Věra; Sovková, Věra; Přikryl, Radek; Vojtová, Lucy. 2020. "FDM 3D Printed Composites for Bone Tissue Engineering Based on Plasticized Poly(3-hydroxybutyrate)/poly(d,l-lactide) Blends" Polymers 12, no. 12: 2806. https://doi.org/10.3390/polym12122806

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