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Article

Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer

1
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
2
Faculty of Experimental Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain
3
Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain
4
Biosanitary Research Institute of Granada (ibs.GRANADA), Andalusian Health Service (SAS), University of Granada, 18100 Granada, Spain
5
Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, 18016 Granada, Spain
6
Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(12), 2790; https://doi.org/10.3390/polym12122790
Received: 2 October 2020 / Revised: 19 November 2020 / Accepted: 23 November 2020 / Published: 25 November 2020
(This article belongs to the Special Issue Nanoparticle Functionalization by Polymers: Methods and Applications)
A reproducible and efficient interfacial polymer disposition method has been used to formulate magnetite/poly(ε-caprolactone) (core/shell) nanoparticles (average size ≈ 125 nm, production performance ≈ 90%). To demonstrate that the iron oxide nuclei were satisfactorily embedded within the polymeric solid matrix, a complete analysis of these nanocomposites by, e.g., electron microscopy visualizations, energy dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, electrophoresis, and contact angle goniometry was conducted. The magnetic responsive behaviour of these nanoparticles was quantitatively characterized by the hysteresis cycle and qualitatively investigated by visualization of the colloid under exposure to a 0.4 T magnet. Gemcitabine entrapment into the polymeric shell reported adequate drug loading values (≈11%), and a biphasic and pH-responsive drug release profile (≈four-fold faster Gemcitabine release at pH 5.0 compared to pH 7.4). Cytotoxicity studies in MCF-7 human breast cancer cells proved that the half maximal inhibitory concentration of Gem-loaded nanocomposites was ≈two-fold less than that of the free drug. Therefore, these core/shell nanoparticles could have great possibilities as a magnetically targeted Gemcitabine delivery system for breast cancer treatment. View Full-Text
Keywords: breast cancer; core/shell; drug loading; Gemcitabine; magnetic drug delivery; magnetite; pH-responsive drug release; poly(ε-caprolactone); polymer-coated nanoparticle breast cancer; core/shell; drug loading; Gemcitabine; magnetic drug delivery; magnetite; pH-responsive drug release; poly(ε-caprolactone); polymer-coated nanoparticle
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MDPI and ACS Style

García-García, G.; Fernández-Álvarez, F.; Cabeza, L.; Delgado, Á.V.; Melguizo, C.; Prados, J.C.; Arias, J.L. Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer. Polymers 2020, 12, 2790. https://doi.org/10.3390/polym12122790

AMA Style

García-García G, Fernández-Álvarez F, Cabeza L, Delgado ÁV, Melguizo C, Prados JC, Arias JL. Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer. Polymers. 2020; 12(12):2790. https://doi.org/10.3390/polym12122790

Chicago/Turabian Style

García-García, Gracia, Fátima Fernández-Álvarez, Laura Cabeza, Ángel V. Delgado, Consolación Melguizo, José C. Prados, and José L. Arias. 2020. "Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer" Polymers 12, no. 12: 2790. https://doi.org/10.3390/polym12122790

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