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Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, China
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2020, 12(10), 2204; https://doi.org/10.3390/polym12102204
Received: 10 September 2020 / Revised: 20 September 2020 / Accepted: 22 September 2020 / Published: 25 September 2020
(This article belongs to the Special Issue Stereocomplexation in Polymers)
Physical crosslinking and chemical crosslinking were used to further improve the mechanical properties and stability of the gel. A temperature/pH dual sensitive and double-crosslinked gel was prepared by the stereo-complex of HEMA-PLLA20 and HEMA-PDLA20 as a physical crosslinking agent, ethylene glycol dimethacrylate (EGDMA) as a chemical crosslinking agent, and azodiisobutyronitrile (AIBN) as an initiator for free radical polymerization. This paper focused on the performance comparison of chemical crosslinked gel, a physical crosslinked gel, and a dual crosslinked gel. The water absorption, temperature, and pH sensitivity of the three hydrogels were studied by a scanning electron microscope (SEM) and swelling performance research. We used a thermal analysis system (TGA) and dynamic viscoelastic spectrometer to study thermal properties and mechanical properties of these gels. Lastly, the in vitro drug release behavior of double-crosslinked hydrogel loaded with doxorubicin under different conditions was studied. The results show that the double-crosslinked and temperature/pH dual responsive hydrogels has great mechanical properties and good stability. View Full-Text
Keywords: double-crosslinked; polylactic acid; temperature/pH sensitive; stereo-complexation double-crosslinked; polylactic acid; temperature/pH sensitive; stereo-complexation
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MDPI and ACS Style

Wang, Z.; Wu, J.; Shi, X.; Song, F.; Gao, W.; Liu, S. Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels. Polymers 2020, 12, 2204. https://doi.org/10.3390/polym12102204

AMA Style

Wang Z, Wu J, Shi X, Song F, Gao W, Liu S. Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels. Polymers. 2020; 12(10):2204. https://doi.org/10.3390/polym12102204

Chicago/Turabian Style

Wang, Zhidan, Jie Wu, Xiaoyu Shi, Fei Song, Wenli Gao, and Shouxin Liu. 2020. "Stereocomplexation of Poly(lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels" Polymers 12, no. 10: 2204. https://doi.org/10.3390/polym12102204

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