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(1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria

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Department of Nanomaterials in Natural Science, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic
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Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic
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Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague, Czech Republic
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Department of Nanomaterials and Informatics, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(1), 206; https://doi.org/10.3390/polym12010206 (registering DOI)
Received: 14 December 2019 / Revised: 8 January 2020 / Accepted: 12 January 2020 / Published: 14 January 2020
An urgent need to find an effective solution to bacterial resistance is pushing worldwide research for highly effective means against this threat. Newly prepared hybrid organosilane fibres consisting of a (1S,2S)-cyclohexane-1,2-diamine derivative, interconnected in the fibre network via covalent bonds, were fully characterised via different techniques, including FTIR, TGA-FTIR, SEM-EDS, and solid-state NMR. Fibrous samples were successfully tested against two types of pathogenic bacterial strains, namely Staphylococcus aureus, and Pseudomonas aeruginosa. The obtained results, showing >99.9% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa in direct contact compared to the control, may help particularly in case of infections, where there is an urgent need to treat the infection in direct contact. From this point of view, the above-mentioned fibrous material may find application in wound healing. Moreover, this new material has a positive impact on fibroblasts viability. View Full-Text
Keywords: organic-inorganic hybrids; organo-bridged silsesquioxane; sol-gel process; electrospinning; Staphylococcus aureus; Pseudomonas aeruginosa organic-inorganic hybrids; organo-bridged silsesquioxane; sol-gel process; electrospinning; Staphylococcus aureus; Pseudomonas aeruginosa
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MDPI and ACS Style

Máková, V.; Holubová, B.; Tetour, D.; Brus, J.; Řezanka, M.; Rysová, M.; Hodačová, J. (1S,2S)-Cyclohexane-1,2-diamine-based Organosilane Fibres as a Powerful Tool Against Pathogenic Bacteria. Polymers 2020, 12, 206.

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