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Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

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Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 7619813159, Iran
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School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Korea
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Department of Textile, Engineering Faculty, University of Bonab, Bonab 5551761167, Iran
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Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz 5166616471, Iran
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Department of Polymer Nano Science and Technology, Department of BIN Fusion Technology and BK-21 Polymer BIN Fusion Research Team, Chonbuk National University, Dukjin, Jeonju 54896, Korea
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Department of Biological Sciences, and Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
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Authors to whom correspondence should be addressed.
Polymers 2020, 12(1), 176; https://doi.org/10.3390/polym12010176
Received: 7 December 2019 / Revised: 5 January 2020 / Accepted: 6 January 2020 / Published: 9 January 2020
The engineering of tissues under a three-dimensional (3D) microenvironment is a great challenge and needs a suitable supporting biomaterial-based scaffold that may facilitate cell attachment, spreading, proliferation, migration, and differentiation for proper tissue regeneration or organ reconstruction. Polysaccharides as natural polymers promise great potential in the preparation of a three-dimensional artificial extracellular matrix (ECM) (i.e., hydrogel) via various processing methods and conditions. Natural polymers, especially gums, based upon hydrogel systems, provide similarities largely with the native ECM and excellent biological response. Here, we review the origin and physico-chemical characteristics of potentially used natural gums. In addition, various forms of scaffolds (e.g., nanofibrous, 3D printed-constructs) based on gums and their efficacy in 3D cell culture and various tissue regenerations such as bone, osteoarthritis and cartilage, skin/wound, retinal, neural, and other tissues are discussed. Finally, the advantages and limitations of natural gums are precisely described for future perspectives in tissue engineering and regenerative medicine in the concluding remarks. View Full-Text
Keywords: natural gums; nanofibrous scaffolds; hydrogels; nanocomposites; extracellular matrix; tissue engineering natural gums; nanofibrous scaffolds; hydrogels; nanocomposites; extracellular matrix; tissue engineering
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MDPI and ACS Style

Mohammadinejad, R.; Kumar, A.; Ranjbar-Mohammadi, M.; Ashrafizadeh, M.; Han, S.S.; Khang, G.; Roveimiab, Z. Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review. Polymers 2020, 12, 176.

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