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Thermo-Mechanical Behaviour of Human Nasal Cartilage

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CMEMS-UMinho, Departamento de Engenharia Mecânica, Universidade do Minho, Campus de Azurém, 4804-533 Guimarães, Portugal
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2C2T—Centro de Ciência e Tecnologia Têxtil, Universidade do Minho, Campus de Azurém, 4804-533 Guimarães, Portugal
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Department of Otolaryngology, Head and Neck Surgery, Santo António Hospital, 4099-001 Porto, Portugal
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HEMS—Histology and Electron Microscopy, i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, 4200-135 Porto, Portugal
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IBMC—Instituto de Biologia Molecular e Celular, University of Porto, 4200-135 Porto, Portugal
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Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto, 4200-135 Porto, Portugal
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Author to whom correspondence should be addressed.
Polymers 2020, 12(1), 177; https://doi.org/10.3390/polym12010177 (registering DOI)
Received: 14 November 2019 / Revised: 18 December 2019 / Accepted: 20 December 2019 / Published: 9 January 2020
(This article belongs to the Section Polymer Analysis)
The aim of this study was to undergo a comprehensive analysis of the thermo-mechanical properties of nasal cartilages for the future design of a composite polymeric material to be used in human nose reconstruction surgery. A thermal and dynamic mechanical analysis (DMA) in tension and compression modes within the ranges 1 to 20 Hz and 30 °C to 250 °C was performed on human nasal cartilage. Differential scanning calorimetry (DSC), as well as characterization of the nasal septum (NS), upper lateral cartilages (ULC), and lower lateral cartilages (LLC) reveals the different nature of the binding water inside the studied specimens. Three peaks at 60–80 °C, 100–130 °C, and 200 °C were attributed to melting of the crystalline region of collagen matrix, water evaporation, and the strongly bound non-interstitial water in the cartilage and composite specimens, respectively. Thermogravimetric analysis (TGA) showed that the degradation of cartilage, composite, and subcutaneous tissue of the NS, ULC, and LLC take place in three thermal events (~37 °C, ~189 °C, and ~290 °C) showing that cartilage releases more water and more rapidly than the subcutaneous tissue. The water content of nasal cartilage was estimated to be 42 wt %. The results of the DMA analyses demonstrated that tensile mode is ruled by flow-independent behaviour produced by the time-dependent deformability of the solid cartilage matrix that is strongly frequency-dependent, showing an unstable crystalline region between 80–180 °C, an amorphous region at around 120 °C, and a clear glass transition point at 200 °C (780 kJ/mol). Instead, the unconfined compressive mode is clearly ruled by a flow-dependent process caused by the frictional force of the interstitial fluid that flows within the cartilage matrix resulting in higher stiffness (from 12 MPa at 1 Hz to 16 MPa at 20 Hz in storage modulus). The outcomes of this study will support the development of an artificial material to mimic the thermo-mechanical behaviour of the natural cartilage of the human nose. View Full-Text
Keywords: cartilage; thermo-mechanical characterization; viscoelasticity; nasal soft tissue; rhinoplasty cartilage; thermo-mechanical characterization; viscoelasticity; nasal soft tissue; rhinoplasty
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MDPI and ACS Style

Fertuzinhos, A.; Teixeira, M.A.; Ferreira, M.G.; Fernandes, R.; Correia, R.; Malheiro, A.R.; Flores, P.; Zille, A.; Dourado, N. Thermo-Mechanical Behaviour of Human Nasal Cartilage. Polymers 2020, 12, 177.

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