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Open AccessArticle

Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized β-Cyclodextrin for Controlled Release of Atropine

1
China-Canada Joint Lab of Food Nutrition and Health (Beijing), School of Food and Health, Beijing Technology &Business University, Beijing 100048, China
2
Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
3
State Key Laboratory of Biobased Material and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China
4
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt
5
Department of Medical Pharmacology, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(1), 130; https://doi.org/10.3390/polym12010130
Received: 2 November 2019 / Revised: 29 December 2019 / Accepted: 31 December 2019 / Published: 6 January 2020
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-β-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template molecule. The effects of different compounds and concentrations of cross-linking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-β-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery. View Full-Text
Keywords: molecularly imprinted polymers; β-cyclodextrin; water-compatible; Atropine; controlled release molecularly imprinted polymers; β-cyclodextrin; water-compatible; Atropine; controlled release
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MDPI and ACS Style

He, Y.; Zeng, S.; Abd El-Aty, A.M.; Hacımüftüoğlu, A.; Kalekristos Yohannes, W.; Khan, M.; She, Y. Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized β-Cyclodextrin for Controlled Release of Atropine. Polymers 2020, 12, 130.

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