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Submicron-Sized Nanocomposite Magnetic-Sensitive Carriers: Controllable Organ Distribution and Biological Effects

1
Skoltech Center of Photonics & Quantum Materials, Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, 3 Nobelya Street, Moscow 121205, Russia
2
Remote Controlled Theranostic Systems Lab, Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia
3
Surface Engineering Labs, Innovative Engineering Technologies Institute, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow 117198, Russia
4
Department of Biotechnology, Bioengineering and Biochemistry, Ogarev Mordovia State University, 68 Bolshevistskaya Street, Saransk 430005, Republic of Mordovia, Russia
5
School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(6), 1082; https://doi.org/10.3390/polym11061082
Received: 30 April 2019 / Revised: 17 June 2019 / Accepted: 21 June 2019 / Published: 25 June 2019
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Abstract

Although new drug delivery systems have been intensely developed in the past decade, no significant increase in the efficiency of drug delivery by nanostructure carriers has been achieved. The reasons are the lack of information about acute toxicity, the influence of the submicron size of the carrier and difficulties with the study of biodistribution in vivo. Here we propose, for the first time in vivo, new nanocomposite submicron carriers made of bovine serum albumin (BSA) and tannic acid (TA) and containing magnetite nanoparticles with sufficient content for navigation in a magnetic field gradient on mice. We examined the efficacy of these submicron carriers as a delivery vehicle in combination with magnetite nanoparticles which were systemically administered intravenously. In addition, the systemic toxicity of this carrier for intravenous administration was explicitly studied. The results showed that (BSA/TA) carriers in the given doses were hemocompatible and didn’t cause any adverse effect on the respiratory system, kidney or liver functions. A combination of gradient-magnetic-field controllable biodistribution of submicron carriers with fluorescence tomography/MRI imaging in vivo provides a new opportunity to improve drug delivery efficiency. View Full-Text
Keywords: submicron-sized particles; bovine serum albumin; tannic acid; carriers; magnetic field gradient; magnetite (MNPs); biodistribution; fluorescent imaging submicron-sized particles; bovine serum albumin; tannic acid; carriers; magnetic field gradient; magnetite (MNPs); biodistribution; fluorescent imaging
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Novoselova, M.V.; German, S.V.; Sindeeva, O.A.; Kulikov, O.A.; Minaeva, O.V.; Brodovskaya, E.P.; Ageev, V.P.; Zharkov, M.N.; Pyataev, N.A.; Sukhorukov, G.B.; Gorin, D.A. Submicron-Sized Nanocomposite Magnetic-Sensitive Carriers: Controllable Organ Distribution and Biological Effects. Polymers 2019, 11, 1082.

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