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Open AccessArticle

Characterization and Optimization of PLA Stereocomplexed Hydrogels for Local Gene Delivery Systems

Department of Chemistry, The University of Memphis, 213 Smith Chemistry Bldg, Memphis, TN 38152, USA
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Author to whom correspondence should be addressed.
Polymers 2019, 11(5), 796; https://doi.org/10.3390/polym11050796
Received: 9 April 2019 / Revised: 29 April 2019 / Accepted: 29 April 2019 / Published: 3 May 2019
(This article belongs to the Special Issue Polymer-Based Systems for Controlled Release and Targeting of Drugs)
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Abstract

Localized gene delivery still remains as a challenging therapeutic method due to the multiple hurdles to overcome. One of the significant factors is a development of a matrix to carry and safely deliver genes at the local site in a controlled manner and then exit and disintegrate harmlessly. This report describes the structural and mechanistic studies on the in-situ forming hydrogels composed of the PEI/DNA multi-layered micelles to apply for gene therapy. The stereocomplexation-driven hydrogel systems from the DNA-loaded and DNA-free PLA-PEG-PLA triblock copolymer micelles that include enantiomeric polylactide blocks exhibited a sol-to-gel transitions between room and body temperatures. These hydrogels have well-described structure and compositions, and improved mechanical properties. Furthermore, the investigation of their degradation profiles and chemical analysis indicated the faster acidic degradation and stepwise degradation process of these micelle–hydrogel systems. View Full-Text
Keywords: hydrogels; micelles; gene delivery; polylactide; stereocomplex; polyethylenimine hydrogels; micelles; gene delivery; polylactide; stereocomplex; polyethylenimine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Liu, K.-Y.; Abebe, D.G.; Wiley, E.R.; Fujiwara, T. Characterization and Optimization of PLA Stereocomplexed Hydrogels for Local Gene Delivery Systems. Polymers 2019, 11, 796.

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