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Open AccessArticle

Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength for Cardiac Tissue Engineering

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School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia
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Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
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Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
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IJNUTM Cardiovascular Engineering center, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia
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Centre for Artificial Intelligence and Robotics, Universiti Teknologi Malaysia, Kuala Lumpur 54100, Malaysia
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School of Electrical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
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Media and Game Innovation Centre of Excellence (MaGICX), Institute of Human Centered Engineering (iHumEn), Universiti Teknologi Malaysia, Skudai 81310, Malaysia
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School of Computing, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia
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Author to whom correspondence should be addressed.
Polymers 2019, 11(4), 705; https://doi.org/10.3390/polym11040705
Received: 18 March 2019 / Revised: 5 April 2019 / Accepted: 11 April 2019 / Published: 17 April 2019
(This article belongs to the Special Issue Electrospun Nanofibers: Theory and Its Applications)
Cardiovascular application of nanomaterial’s is of increasing demand and its usage is limited by its mechanical and blood compatible properties. In this work, an attempt is made to develop an electrospun novel nanocomposite loaded with basil oil and titanium dioxide (TiO2) particles. The composite material displayed increase in hydrophobic and reduced fiber diameter compared to the pristine polymer. Fourier transform infrared spectroscopy results showed the interaction of the pristine polymer with the added substances. Thermal analysis showed the increased onset degradation, whereas the mechanical testing portrayed the increased tensile strength of the composites. Finally, the composite delayed the coagulation times and also rendered safe environment for red blood cells signifying its suitability to be used in contact with blood. Strikingly, the cellular toxicity of the developed composite was lower than the pristine polymer suggesting its compatible nature with the surrounding tissues. With these promising characteristics, developed material with enhanced physicochemical properties and blood compatibility can be successfully utilized for cardiac tissue applications. View Full-Text
Keywords: polyurethane; basil/titanium dioxide; physico-chemical properties; biocompatibility; cardiac tissue applications polyurethane; basil/titanium dioxide; physico-chemical properties; biocompatibility; cardiac tissue applications
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MDPI and ACS Style

Mani, M.P.; Jaganathan, S.K.; Faudzi, A.A.M.; Sunar, M.S. Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength for Cardiac Tissue Engineering. Polymers 2019, 11, 705.

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