Next Article in Journal
Recycled-Oil-Based Polyurethane Modified with Organic Silicone for Controllable Release of Coated Fertilizer
Previous Article in Journal
Effect of Chemical Structure and Salt Concentration on the Crystallization and Ionic Conductivity of Aliphatic Polyethers
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Polymers 2019, 11(3), 453; https://doi.org/10.3390/polym11030453

Carbon Nanofibers in Pure Form and in Calcium Alginate Composites Films: New Cost-Effective Antibacterial Biomaterials against the Life-Threatening Multidrug-Resistant Staphylococcus epidermidis

Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 13 January 2019 / Revised: 26 February 2019 / Accepted: 5 March 2019 / Published: 10 March 2019
(This article belongs to the Special Issue Multifunctional Polymeric Biomaterials)
Full-Text   |   PDF [2841 KB, uploaded 10 March 2019]   |  

Abstract

Due to the current global health problem of antibiotic resistant recently announced by the World Health Organization, there is an urgent necessity of looking for new alternative antibacterial materials able to treat and impede multidrug-resistant infections which are cost-effective and non-toxic for human beings. In this regard, carbon nanofibers (CNFs) possess currently much lower cost than other carbon nanomaterials, such as graphene oxide, and exhibit excellent chemical, mechanical and electric properties. Furthermore, here, the first report on the antibacterial activity of CNFs was demonstrated. Thus, these nanomaterials, in pure form or incorporated in a minuscule amount into calcium alginate composite films to reduce production costs as much as possible, showed to be new weapons against a globally spreading multidrug-resistant pathogen, the methicillin-resistant Staphylococcus epidermidis (MRSE). This Gram-positive bacterium is becoming one of the most dangerous pathogens, due to its abundance on skin. In this study, these hollow filamentous materials, in direct contact with cells and loaded in the low-cost calcium alginate composite films, showed no cytotoxicity for human keratinocyte HaCaT cells, which render them very promising for biomedical applications. The CNFs used in this work were characterized by Raman spectroscopy and observed by high-resolution transmission electron with energy-disperse X-ray spectroscopy. View Full-Text
Keywords: carbon nanofibers; calcium alginate; antibacterial activity; Staphylococcus epidermidis; multidrug-resistant bacteria; human keratinocyte HaCaT cells; cytotoxicity carbon nanofibers; calcium alginate; antibacterial activity; Staphylococcus epidermidis; multidrug-resistant bacteria; human keratinocyte HaCaT cells; cytotoxicity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Salesa, B.; Martí, M.; Frígols, B.; Serrano-Aroca, Á. Carbon Nanofibers in Pure Form and in Calcium Alginate Composites Films: New Cost-Effective Antibacterial Biomaterials against the Life-Threatening Multidrug-Resistant Staphylococcus epidermidis. Polymers 2019, 11, 453.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top