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Open AccessArticle

Facile Preparation of Reduction-Responsive Micelles Based on Biodegradable Amphiphilic Polyurethane with Disulfide Bonds in the Backbone

1
School of Chemistry & Materials Science, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, China
2
School of Life Science, Jiangsu Normal University, Xuzhou 221116, China
3
Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2019, 11(2), 262; https://doi.org/10.3390/polym11020262
Received: 3 January 2019 / Revised: 30 January 2019 / Accepted: 30 January 2019 / Published: 4 February 2019
(This article belongs to the Special Issue Polymer-Based Systems for Controlled Release and Targeting of Drugs)
In this paper, we synthesized a biodegradable amphiphilic polymer of polyurethane-polyethylene glycol with disulfide bonds in the main chain (PEG-PU(SS)-PEG). DLS and SEM showed that the polymer could self-assemble into micelles in aqueous solution and could be used to load the hydrophobic anticancer drug DOX. Intriguingly, drug release in vitro indicated that DOX-loaded PEG-PU(SS)-PEG micelles had good stability under the extracellular physiological environment, but the disulfide bonds broke rapidly and DOX was released quickly under the intracellular reducing conditions. CCK-8 assays showed that DOX-loaded PEG-PU(SS)-PEG micelles had a high in vitro antitumor activity in C6 cells, whereas blank PEG-PU(SS)-PEG micelles were nontoxic to C6 cells. It was also found that there was strong and persistent accumulation of DOX-loaded PEG-PU(SS)-PEG as compared with PEG-PU-PEG both by the cell internalization tests and the flow cytometry measurements. Hence, PEG-PU(SS)-PEG micelles will have a potential use for clinical treatment of cancer in the future. View Full-Text
Keywords: reduction-responsive; micelles; polyurethane; triggered release reduction-responsive; micelles; polyurethane; triggered release
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MDPI and ACS Style

Zhang, P.; Hu, J.; Bu, L.; Zhang, H.; Du, B.; Zhu, C.; Li, Y. Facile Preparation of Reduction-Responsive Micelles Based on Biodegradable Amphiphilic Polyurethane with Disulfide Bonds in the Backbone. Polymers 2019, 11, 262.

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