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Polymers 2019, 11(1), 108; https://doi.org/10.3390/polym11010108

Starch-Based Pickering Emulsions as Platforms for Topical Antibiotic Delivery: In Vitro and In Vivo Studies

1
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1609-003 Lisbon, Portugal
2
Centro de Investigação Interdisciplinar Egas Moniz, Campus Universitário, Quinta da Granja, 2829-511 Monte de Caparica, Portugal
*
Author to whom correspondence should be addressed.
Received: 7 December 2018 / Revised: 27 December 2018 / Accepted: 7 January 2019 / Published: 10 January 2019
(This article belongs to the Special Issue Polymer-based Systems for Controlled Release and Targeting of Drugs)
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Abstract

The present study investigated a new approach to treat superficial skin infections by topical application of minocycline hydrochloride (MH) formulated in a novel starch-based Pickering emulsion (ASt-emulsions). The emulsions were fully characterized in terms of efficacy, as well as in vitro release and permeation studies. The emulsions provided a prolonged MH release, always above its minimum inhibitory concentration against Staphylococcus aureus, although the drug did not permeate through the entire skin layer. The in vitro antibacterial activity of MHASt-emulsions against S. aureus was confirmed and their therapeutic efficacy was assessed using an in vitro skin-adapted agar diffusion test. In vivo antibacterial activity, evaluated using the tape-stripping infection model in mice, showed the topical administration of MH was effective against superficial infections caused by S. aureus. This study supports the potential of ASt-emulsions as promising platforms for topical antibiotic delivery, contributing to a new perspective on the treatment of superficial bacterial infections. View Full-Text
Keywords: starch; modified starch; Pickering emulsions; minocycline; superficial skin infection; topical application starch; modified starch; Pickering emulsions; minocycline; superficial skin infection; topical application
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Marto, J.; Duarte, A.; Simões, S.; Gonçalves, L.M.; Gouveia, L.F.; Almeida, A.J.; Ribeiro, H.M. Starch-Based Pickering Emulsions as Platforms for Topical Antibiotic Delivery: In Vitro and In Vivo Studies. Polymers 2019, 11, 108.

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