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Open AccessArticle

Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers

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CDRsp-IPL-Centre Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, 2430-028 Marinha Grande, Portugal
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CICS-UBI-Health Sciences Research Centre, Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal
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Author to whom correspondence should be addressed.
Polymers 2019, 11(12), 1949; https://doi.org/10.3390/polym11121949
Received: 22 October 2019 / Revised: 22 November 2019 / Accepted: 24 November 2019 / Published: 27 November 2019
(This article belongs to the Section Biopolymers)
Microparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse effects, and hence an improvement in bioavailability. Among the studied microparticles, there is a rising interest in the research of alginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used as an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the most extensively forming microparticles in the presence of divalent cations providing prolonged drug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research work, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high encapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect, and high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal combination among the percentage of alginate and CaCl2, design of Experiments was applied. The obtained model presented to be statistically significant (p-value < 0.05), with a coefficient of determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling, and sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was successfully validated. View Full-Text
Keywords: alginate; Design of Experiments; electrospraying; microparticles; protein release alginate; Design of Experiments; electrospraying; microparticles; protein release
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MDPI and ACS Style

Valente, J.; Dias, J.; Sousa, A.; Alves, N. Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers. Polymers 2019, 11, 1949.

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